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TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas

This study investigates the expression and prognostic value of TRIM6 in gliomas, the most prevalent primary brain and spinal cord tumors. Our results show that TRIM6 is predominantly overexpressed in glioma tissues and is associated with reduced overall survival, disease-specific survival, and progr...

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Autores principales: Guo, Jianrong, Feng, Shoucheng, Liu, Hong, Chen, Zhuopeng, Ding, Chao, Jin, Yukai, Chen, Xiaojiang, Ling, Yudong, Zeng, Yi, Long, Hao, Qiu, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527026/
https://www.ncbi.nlm.nih.gov/pubmed/37759698
http://dx.doi.org/10.3390/biom13091298
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author Guo, Jianrong
Feng, Shoucheng
Liu, Hong
Chen, Zhuopeng
Ding, Chao
Jin, Yukai
Chen, Xiaojiang
Ling, Yudong
Zeng, Yi
Long, Hao
Qiu, Haibo
author_facet Guo, Jianrong
Feng, Shoucheng
Liu, Hong
Chen, Zhuopeng
Ding, Chao
Jin, Yukai
Chen, Xiaojiang
Ling, Yudong
Zeng, Yi
Long, Hao
Qiu, Haibo
author_sort Guo, Jianrong
collection PubMed
description This study investigates the expression and prognostic value of TRIM6 in gliomas, the most prevalent primary brain and spinal cord tumors. Our results show that TRIM6 is predominantly overexpressed in glioma tissues and is associated with reduced overall survival, disease-specific survival, and progression-free interval. Furthermore, TRIM6 expression is correlated with WHO grade and primary treatment outcomes. Functional analysis indicates that interactions between cytokines and their receptors play a critical role in the prognosis of glioma patients. A protein-protein interaction network reveals 10 hub genes closely linked to cytokine-cytokine receptor interaction. In vitro experiments demonstrate that silencing TRIM6 impairs the proliferation, invasion, and migration of glioma cells, while overexpressing TRIM6 enhances these abilities. Additionally, TRIM6 expression is positively associated with the abundance of innate immune cells and negatively associated with the abundance of adaptive immune cells. In summary, TRIM6 is significantly upregulated in gliomas and linked to poor prognosis, making it a potential diagnostic and prognostic biomarker. TRIM6 plays a crucial role in promoting cell viability, clonogenic potential, migration, and invasion in glioma cells. It may regulate glioma progression by modulating cytokine-cytokine receptor interaction, leading to an inflammatory response and an imbalance in immunomodulation, thereby representing a potential therapeutic target.
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spelling pubmed-105270262023-09-28 TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas Guo, Jianrong Feng, Shoucheng Liu, Hong Chen, Zhuopeng Ding, Chao Jin, Yukai Chen, Xiaojiang Ling, Yudong Zeng, Yi Long, Hao Qiu, Haibo Biomolecules Article This study investigates the expression and prognostic value of TRIM6 in gliomas, the most prevalent primary brain and spinal cord tumors. Our results show that TRIM6 is predominantly overexpressed in glioma tissues and is associated with reduced overall survival, disease-specific survival, and progression-free interval. Furthermore, TRIM6 expression is correlated with WHO grade and primary treatment outcomes. Functional analysis indicates that interactions between cytokines and their receptors play a critical role in the prognosis of glioma patients. A protein-protein interaction network reveals 10 hub genes closely linked to cytokine-cytokine receptor interaction. In vitro experiments demonstrate that silencing TRIM6 impairs the proliferation, invasion, and migration of glioma cells, while overexpressing TRIM6 enhances these abilities. Additionally, TRIM6 expression is positively associated with the abundance of innate immune cells and negatively associated with the abundance of adaptive immune cells. In summary, TRIM6 is significantly upregulated in gliomas and linked to poor prognosis, making it a potential diagnostic and prognostic biomarker. TRIM6 plays a crucial role in promoting cell viability, clonogenic potential, migration, and invasion in glioma cells. It may regulate glioma progression by modulating cytokine-cytokine receptor interaction, leading to an inflammatory response and an imbalance in immunomodulation, thereby representing a potential therapeutic target. MDPI 2023-08-24 /pmc/articles/PMC10527026/ /pubmed/37759698 http://dx.doi.org/10.3390/biom13091298 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Jianrong
Feng, Shoucheng
Liu, Hong
Chen, Zhuopeng
Ding, Chao
Jin, Yukai
Chen, Xiaojiang
Ling, Yudong
Zeng, Yi
Long, Hao
Qiu, Haibo
TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas
title TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas
title_full TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas
title_fullStr TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas
title_full_unstemmed TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas
title_short TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas
title_sort trim6: an upregulated biomarker with prognostic significance and immune correlations in gliomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527026/
https://www.ncbi.nlm.nih.gov/pubmed/37759698
http://dx.doi.org/10.3390/biom13091298
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