Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry

The high structural similarity, especially in transmembrane regions, of dopamine, norepinephrine, and serotonin transporters, as well as the lack of all crystal structures of human isoforms, make the specific targeting of individual transporters rather challenging. Ligand design itself is also rathe...

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Detalles Bibliográficos
Autores principales: Kalaba, Predrag, Pacher, Katharina, Neill, Philip John, Dragacevic, Vladimir, Zehl, Martin, Wackerlig, Judith, Kirchhofer, Michael, Sartori, Simone B., Gstach, Hubert, Kouhnavardi, Shima, Fabisikova, Anna, Pillwein, Matthias, Monje-Quiroga, Francisco, Ebner, Karl, Prado-Roller, Alexander, Singewald, Nicolas, Urban, Ernst, Langer, Thierry, Pifl, Christian, Lubec, Jana, Leban, Johann Jakob, Lubec, Gert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527105/
https://www.ncbi.nlm.nih.gov/pubmed/37759815
http://dx.doi.org/10.3390/biom13091415

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