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Achieving Nasal Septal Cartilage In Situ Regeneration: Focus on Cartilage Progenitor Cells

The nasal septal cartilage plays an important role in preventing the collapse of the nasal bones and maintaining the appearance of the nose. In the context of inherent difficulties regarding septal cartilage repair and the shortage of cartilage graft resources for regeneration, tissue engineering, e...

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Detalles Bibliográficos
Autores principales: Zhang, Chong, Wang, Guanhuier, An, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527213/
https://www.ncbi.nlm.nih.gov/pubmed/37759702
http://dx.doi.org/10.3390/biom13091302
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author Zhang, Chong
Wang, Guanhuier
An, Yang
author_facet Zhang, Chong
Wang, Guanhuier
An, Yang
author_sort Zhang, Chong
collection PubMed
description The nasal septal cartilage plays an important role in preventing the collapse of the nasal bones and maintaining the appearance of the nose. In the context of inherent difficulties regarding septal cartilage repair and the shortage of cartilage graft resources for regeneration, tissue engineering, especially the in situ strategy based on scaffolds, has become a new prospect and become one of the most promising approaches. Given that it is difficult for chondrocytes to achieve directional migration and secrete matrix components to participate in tissue repair after cartilage injury, cartilage progenitor cells (CPCs), with great migratory ability and stem cell characteristics, have caught the attention of researchers and brought hope for nasal septal cartilage in situ regeneration. In this review, we first summarized the distribution, characteristics, isolation, and culture methods of nasal septal CPCs. Subsequently, we described the roles of migratory CPCs in cartilage regeneration. Finally, we reviewed the existing studies on CPCs-based cartilage tissue engineering and summarized the strategies for promoting the migration and chondrogenesis of CPCs so as to provide ideas for achieving nasal septal cartilage in situ regeneration.
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spelling pubmed-105272132023-09-28 Achieving Nasal Septal Cartilage In Situ Regeneration: Focus on Cartilage Progenitor Cells Zhang, Chong Wang, Guanhuier An, Yang Biomolecules Review The nasal septal cartilage plays an important role in preventing the collapse of the nasal bones and maintaining the appearance of the nose. In the context of inherent difficulties regarding septal cartilage repair and the shortage of cartilage graft resources for regeneration, tissue engineering, especially the in situ strategy based on scaffolds, has become a new prospect and become one of the most promising approaches. Given that it is difficult for chondrocytes to achieve directional migration and secrete matrix components to participate in tissue repair after cartilage injury, cartilage progenitor cells (CPCs), with great migratory ability and stem cell characteristics, have caught the attention of researchers and brought hope for nasal septal cartilage in situ regeneration. In this review, we first summarized the distribution, characteristics, isolation, and culture methods of nasal septal CPCs. Subsequently, we described the roles of migratory CPCs in cartilage regeneration. Finally, we reviewed the existing studies on CPCs-based cartilage tissue engineering and summarized the strategies for promoting the migration and chondrogenesis of CPCs so as to provide ideas for achieving nasal septal cartilage in situ regeneration. MDPI 2023-08-25 /pmc/articles/PMC10527213/ /pubmed/37759702 http://dx.doi.org/10.3390/biom13091302 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Chong
Wang, Guanhuier
An, Yang
Achieving Nasal Septal Cartilage In Situ Regeneration: Focus on Cartilage Progenitor Cells
title Achieving Nasal Septal Cartilage In Situ Regeneration: Focus on Cartilage Progenitor Cells
title_full Achieving Nasal Septal Cartilage In Situ Regeneration: Focus on Cartilage Progenitor Cells
title_fullStr Achieving Nasal Septal Cartilage In Situ Regeneration: Focus on Cartilage Progenitor Cells
title_full_unstemmed Achieving Nasal Septal Cartilage In Situ Regeneration: Focus on Cartilage Progenitor Cells
title_short Achieving Nasal Septal Cartilage In Situ Regeneration: Focus on Cartilage Progenitor Cells
title_sort achieving nasal septal cartilage in situ regeneration: focus on cartilage progenitor cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527213/
https://www.ncbi.nlm.nih.gov/pubmed/37759702
http://dx.doi.org/10.3390/biom13091302
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