Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression

Mutations in the transcription factor-coding gene SOX18, the growth factor-coding gene VEGFC and its receptor-coding gene VEGFR3/FLT4 cause primary lymphedema in humans. In mammals, SOX18, together with COUP-TFII/NR2F2, activates the expression of Prox1, a master regulator in lymphatic identity and...

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Detalles Bibliográficos
Autores principales: Moleri, Silvia, Mercurio, Sara, Pezzotta, Alex, D’Angelo, Donatella, Brix, Alessia, Plebani, Alice, Lini, Giulia, Di Fuorti, Marialaura, Beltrame, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527217/
https://www.ncbi.nlm.nih.gov/pubmed/37759531
http://dx.doi.org/10.3390/cells12182309

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