Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO(2) NPs) for Hemostatic Applications

In this study, a novel absorbable hemostatic agent was developed using carrageenan (CRG) as a natural polymer and cerium oxide nanoparticles (CeO(2) NPs). CRG-CeO(2)-0.5 and CRG-CeO(2)-1 composites were prepared by compositing CeO(2) to CRG + CeO(2) at a weight ratio of 0.5:100 and 1:100, respective...

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Autores principales: Alizadeh, Kimia, Dezvare, Yasaman, Kamyab, Shirin, Amirian, Jhaleh, Brangule, Agnese, Bandere, Dace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527261/
https://www.ncbi.nlm.nih.gov/pubmed/37754160
http://dx.doi.org/10.3390/biomimetics8050409
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author Alizadeh, Kimia
Dezvare, Yasaman
Kamyab, Shirin
Amirian, Jhaleh
Brangule, Agnese
Bandere, Dace
author_facet Alizadeh, Kimia
Dezvare, Yasaman
Kamyab, Shirin
Amirian, Jhaleh
Brangule, Agnese
Bandere, Dace
author_sort Alizadeh, Kimia
collection PubMed
description In this study, a novel absorbable hemostatic agent was developed using carrageenan (CRG) as a natural polymer and cerium oxide nanoparticles (CeO(2) NPs). CRG-CeO(2)-0.5 and CRG-CeO(2)-1 composites were prepared by compositing CeO(2) to CRG + CeO(2) at a weight ratio of 0.5:100 and 1:100, respectively. The physicochemical and structural properties of these compounds were studied and compared with pristine CRG. Upon incorporation of CeO(2) nanoparticles into the CRG matrix, significant reductions in hydrogel degradation were observed. In addition, it was noted that CRG-CeO(2) exhibited better antibacterial and hemostatic properties than CRG hydrogel without CeO(2) NPs. The biocompatibility of the materials was tested using the NIH 3T3 cell line, and all samples were found to be nontoxic. Particularly, CRG-CeO(2)-1 demonstrated superior hemostatic effects, biocompatibility, and a lower degradation rate since more CeO(2) NPs were present in the CRG matrix. Therefore, CRG-CeO(2)-1 has the potential to be used as a hemostatic agent and wound dressing.
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spelling pubmed-105272612023-09-28 Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO(2) NPs) for Hemostatic Applications Alizadeh, Kimia Dezvare, Yasaman Kamyab, Shirin Amirian, Jhaleh Brangule, Agnese Bandere, Dace Biomimetics (Basel) Article In this study, a novel absorbable hemostatic agent was developed using carrageenan (CRG) as a natural polymer and cerium oxide nanoparticles (CeO(2) NPs). CRG-CeO(2)-0.5 and CRG-CeO(2)-1 composites were prepared by compositing CeO(2) to CRG + CeO(2) at a weight ratio of 0.5:100 and 1:100, respectively. The physicochemical and structural properties of these compounds were studied and compared with pristine CRG. Upon incorporation of CeO(2) nanoparticles into the CRG matrix, significant reductions in hydrogel degradation were observed. In addition, it was noted that CRG-CeO(2) exhibited better antibacterial and hemostatic properties than CRG hydrogel without CeO(2) NPs. The biocompatibility of the materials was tested using the NIH 3T3 cell line, and all samples were found to be nontoxic. Particularly, CRG-CeO(2)-1 demonstrated superior hemostatic effects, biocompatibility, and a lower degradation rate since more CeO(2) NPs were present in the CRG matrix. Therefore, CRG-CeO(2)-1 has the potential to be used as a hemostatic agent and wound dressing. MDPI 2023-09-04 /pmc/articles/PMC10527261/ /pubmed/37754160 http://dx.doi.org/10.3390/biomimetics8050409 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alizadeh, Kimia
Dezvare, Yasaman
Kamyab, Shirin
Amirian, Jhaleh
Brangule, Agnese
Bandere, Dace
Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO(2) NPs) for Hemostatic Applications
title Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO(2) NPs) for Hemostatic Applications
title_full Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO(2) NPs) for Hemostatic Applications
title_fullStr Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO(2) NPs) for Hemostatic Applications
title_full_unstemmed Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO(2) NPs) for Hemostatic Applications
title_short Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO(2) NPs) for Hemostatic Applications
title_sort development of composite sponge scaffolds based on carrageenan (crg) and cerium oxide nanoparticles (ceo(2) nps) for hemostatic applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527261/
https://www.ncbi.nlm.nih.gov/pubmed/37754160
http://dx.doi.org/10.3390/biomimetics8050409
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