The Genetics of Coronary Artery Disease: A Vascular Perspective

Genome-wide association studies (GWAS) have identified a large number of genetic loci for coronary artery disease (CAD), with many located close to genes associated with traditional CAD risk pathways, such as lipid metabolism and inflammation. It is becoming evident with recent CAD GWAS meta-analyse...

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Detalles Bibliográficos
Autores principales: Quaye, Leon N. K., Dalzell, Catherine E., Deloukas, Panos, Smith, Andrew J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527262/
https://www.ncbi.nlm.nih.gov/pubmed/37759455
http://dx.doi.org/10.3390/cells12182232
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author Quaye, Leon N. K.
Dalzell, Catherine E.
Deloukas, Panos
Smith, Andrew J. P.
author_facet Quaye, Leon N. K.
Dalzell, Catherine E.
Deloukas, Panos
Smith, Andrew J. P.
author_sort Quaye, Leon N. K.
collection PubMed
description Genome-wide association studies (GWAS) have identified a large number of genetic loci for coronary artery disease (CAD), with many located close to genes associated with traditional CAD risk pathways, such as lipid metabolism and inflammation. It is becoming evident with recent CAD GWAS meta-analyses that vascular pathways are also highly enriched and present an opportunity for novel therapeutics. This review examines GWAS-enriched vascular gene loci, the pathways involved and their potential role in CAD pathogenesis. The functionality of variants is explored from expression quantitative trait loci, massively parallel reporter assays and CRISPR-based gene-editing tools. We discuss how this research may lead to novel therapeutic tools to treat cardiovascular disorders.
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spelling pubmed-105272622023-09-28 The Genetics of Coronary Artery Disease: A Vascular Perspective Quaye, Leon N. K. Dalzell, Catherine E. Deloukas, Panos Smith, Andrew J. P. Cells Review Genome-wide association studies (GWAS) have identified a large number of genetic loci for coronary artery disease (CAD), with many located close to genes associated with traditional CAD risk pathways, such as lipid metabolism and inflammation. It is becoming evident with recent CAD GWAS meta-analyses that vascular pathways are also highly enriched and present an opportunity for novel therapeutics. This review examines GWAS-enriched vascular gene loci, the pathways involved and their potential role in CAD pathogenesis. The functionality of variants is explored from expression quantitative trait loci, massively parallel reporter assays and CRISPR-based gene-editing tools. We discuss how this research may lead to novel therapeutic tools to treat cardiovascular disorders. MDPI 2023-09-08 /pmc/articles/PMC10527262/ /pubmed/37759455 http://dx.doi.org/10.3390/cells12182232 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Quaye, Leon N. K.
Dalzell, Catherine E.
Deloukas, Panos
Smith, Andrew J. P.
The Genetics of Coronary Artery Disease: A Vascular Perspective
title The Genetics of Coronary Artery Disease: A Vascular Perspective
title_full The Genetics of Coronary Artery Disease: A Vascular Perspective
title_fullStr The Genetics of Coronary Artery Disease: A Vascular Perspective
title_full_unstemmed The Genetics of Coronary Artery Disease: A Vascular Perspective
title_short The Genetics of Coronary Artery Disease: A Vascular Perspective
title_sort genetics of coronary artery disease: a vascular perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527262/
https://www.ncbi.nlm.nih.gov/pubmed/37759455
http://dx.doi.org/10.3390/cells12182232
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