Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy

Aging is associated with the disruption of protein homeostasis and causally contributes to multiple diseases, including amyotrophic lateral sclerosis (ALS). One strategy for restoring protein homeostasis and protecting neurons against age-dependent diseases such as ALS is to de-repress autophagy. BE...

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Detalles Bibliográficos
Autores principales: Castillo Bautista, Cristina Marisol, Eismann, Kristin, Gentzel, Marc, Pelucchi, Silvia, Mertens, Jerome, Walters, Hannah E., Yun, Maximina H., Sterneckert, Jared
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527391/
https://www.ncbi.nlm.nih.gov/pubmed/37759469
http://dx.doi.org/10.3390/cells12182247

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