Progerin, an Aberrant Spliced Form of Lamin A, Is a Potential Therapeutic Target for HGPS

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder caused by the mutant protein progerin, which is expressed by the abnormal splicing of the LMNA gene. HGPS affects systemic levels, with the exception of cognition or brain development, in children, showing that cellula...

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Detalles Bibliográficos
Autores principales: Kim, Bae-Hoon, Chung, Yeon-Ho, Woo, Tae-Gyun, Kang, So-Mi, Park, Soyoung, Park, Bum-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527460/
https://www.ncbi.nlm.nih.gov/pubmed/37759521
http://dx.doi.org/10.3390/cells12182299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527460/
https://www.ncbi.nlm.nih.gov/pubmed/37759521
http://dx.doi.org/10.3390/cells12182299

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