Characterizing expression pattern of Six2Cre during mouse craniofacial development

Craniofacial development is a complex process involving diverse cell populations. Various transgenic Cre lines have been developed to facilitate studying gene function in specific tissues. In this study, we have characterized the expression pattern of Six2Cre mice at multiple stages during craniofac...

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Detalles Bibliográficos
Autores principales: Umar, Meenakshi, Dong, Chunmin, He, Fenglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527692/
https://www.ncbi.nlm.nih.gov/pubmed/36999646
http://dx.doi.org/10.1002/dvg.23516
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author Umar, Meenakshi
Dong, Chunmin
He, Fenglei
author_facet Umar, Meenakshi
Dong, Chunmin
He, Fenglei
author_sort Umar, Meenakshi
collection PubMed
description Craniofacial development is a complex process involving diverse cell populations. Various transgenic Cre lines have been developed to facilitate studying gene function in specific tissues. In this study, we have characterized the expression pattern of Six2Cre mice at multiple stages during craniofacial development. Our data revealed that Six2Cre lineage cells are predominantly present in frontal bone, mandible, and secondary palate. Using immunostaining method, we found that Six2Cre triggered reporter is co-expressed with Runx2. In summary, our data showed Six2Cre can be used to study gene function during palate development and osteogenesis in mouse models.
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spelling pubmed-105276922023-09-27 Characterizing expression pattern of Six2Cre during mouse craniofacial development Umar, Meenakshi Dong, Chunmin He, Fenglei Genesis Article Craniofacial development is a complex process involving diverse cell populations. Various transgenic Cre lines have been developed to facilitate studying gene function in specific tissues. In this study, we have characterized the expression pattern of Six2Cre mice at multiple stages during craniofacial development. Our data revealed that Six2Cre lineage cells are predominantly present in frontal bone, mandible, and secondary palate. Using immunostaining method, we found that Six2Cre triggered reporter is co-expressed with Runx2. In summary, our data showed Six2Cre can be used to study gene function during palate development and osteogenesis in mouse models. 2023-09 2023-03-31 /pmc/articles/PMC10527692/ /pubmed/36999646 http://dx.doi.org/10.1002/dvg.23516 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Article
Umar, Meenakshi
Dong, Chunmin
He, Fenglei
Characterizing expression pattern of Six2Cre during mouse craniofacial development
title Characterizing expression pattern of Six2Cre during mouse craniofacial development
title_full Characterizing expression pattern of Six2Cre during mouse craniofacial development
title_fullStr Characterizing expression pattern of Six2Cre during mouse craniofacial development
title_full_unstemmed Characterizing expression pattern of Six2Cre during mouse craniofacial development
title_short Characterizing expression pattern of Six2Cre during mouse craniofacial development
title_sort characterizing expression pattern of six2cre during mouse craniofacial development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527692/
https://www.ncbi.nlm.nih.gov/pubmed/36999646
http://dx.doi.org/10.1002/dvg.23516
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AT dongchunmin characterizingexpressionpatternofsix2creduringmousecraniofacialdevelopment
AT hefenglei characterizingexpressionpatternofsix2creduringmousecraniofacialdevelopment

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