Dysregulation of Cholesterol Homeostasis in Ovarian Cancer

Cholesterol plays an essential role in maintaining the rigidity of cell membranes and signal transduction. Various investigations confirmed empirically that the dysregulation of cholesterol homeostasis positively correlates with tumor progression. More specifically, recent studies suggested the dist...

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Detalles Bibliográficos
Autores principales: Qusairy, Zahraa, Gangloff, Anne, Leung, Shuk On Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527727/
https://www.ncbi.nlm.nih.gov/pubmed/37754524
http://dx.doi.org/10.3390/curroncol30090609
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author Qusairy, Zahraa
Gangloff, Anne
Leung, Shuk On Annie
author_facet Qusairy, Zahraa
Gangloff, Anne
Leung, Shuk On Annie
author_sort Qusairy, Zahraa
collection PubMed
description Cholesterol plays an essential role in maintaining the rigidity of cell membranes and signal transduction. Various investigations confirmed empirically that the dysregulation of cholesterol homeostasis positively correlates with tumor progression. More specifically, recent studies suggested the distinct role of cholesterol in ovarian cancer cell proliferation, metastasis and chemoresistance. In this review, we summarize the current findings that suggest the contribution of cholesterol homeostasis dysregulation to ovarian cancer progression and resistance to anti-cancer agents. We also discuss the therapeutic implications of cholesterol-lowering drugs in ovarian cancer.
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spelling pubmed-105277272023-09-28 Dysregulation of Cholesterol Homeostasis in Ovarian Cancer Qusairy, Zahraa Gangloff, Anne Leung, Shuk On Annie Curr Oncol Review Cholesterol plays an essential role in maintaining the rigidity of cell membranes and signal transduction. Various investigations confirmed empirically that the dysregulation of cholesterol homeostasis positively correlates with tumor progression. More specifically, recent studies suggested the distinct role of cholesterol in ovarian cancer cell proliferation, metastasis and chemoresistance. In this review, we summarize the current findings that suggest the contribution of cholesterol homeostasis dysregulation to ovarian cancer progression and resistance to anti-cancer agents. We also discuss the therapeutic implications of cholesterol-lowering drugs in ovarian cancer. MDPI 2023-09-13 /pmc/articles/PMC10527727/ /pubmed/37754524 http://dx.doi.org/10.3390/curroncol30090609 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Qusairy, Zahraa
Gangloff, Anne
Leung, Shuk On Annie
Dysregulation of Cholesterol Homeostasis in Ovarian Cancer
title Dysregulation of Cholesterol Homeostasis in Ovarian Cancer
title_full Dysregulation of Cholesterol Homeostasis in Ovarian Cancer
title_fullStr Dysregulation of Cholesterol Homeostasis in Ovarian Cancer
title_full_unstemmed Dysregulation of Cholesterol Homeostasis in Ovarian Cancer
title_short Dysregulation of Cholesterol Homeostasis in Ovarian Cancer
title_sort dysregulation of cholesterol homeostasis in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527727/
https://www.ncbi.nlm.nih.gov/pubmed/37754524
http://dx.doi.org/10.3390/curroncol30090609
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