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Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments

Neurodegenerative diseases (NDs) impose substantial medical and public health burdens on people worldwide and represent one of the major threats to human health. The prevalence of these age‐dependent disorders is dramatically increasing over time, a process intrinsically related to a constantly risi...

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Autores principales: Scarpa, Edoardo, Cascione, Mariafrancesca, Griego, Anna, Pellegrino, Paolo, Moschetti, Giorgia, De Matteis, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527799/
https://www.ncbi.nlm.nih.gov/pubmed/37786760
http://dx.doi.org/10.1002/ibra.12126
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author Scarpa, Edoardo
Cascione, Mariafrancesca
Griego, Anna
Pellegrino, Paolo
Moschetti, Giorgia
De Matteis, Valeria
author_facet Scarpa, Edoardo
Cascione, Mariafrancesca
Griego, Anna
Pellegrino, Paolo
Moschetti, Giorgia
De Matteis, Valeria
author_sort Scarpa, Edoardo
collection PubMed
description Neurodegenerative diseases (NDs) impose substantial medical and public health burdens on people worldwide and represent one of the major threats to human health. The prevalence of these age‐dependent disorders is dramatically increasing over time, a process intrinsically related to a constantly rising percentage of the elderly population in recent years. Among all the NDs, Alzheimer's and Parkinson's are considered the most debilitating as they cause memory and cognitive loss, as well as severely affecting basic physiological conditions such as the ability to move, speak, and breathe. There is an extreme need for new and more effective therapies to counteract these devastating diseases, as the available treatments are only able to slow down the pathogenic process without really stopping or resolving it. This review aims to elucidate the current nanotechnology‐based tools representing a future hope for NDs treatment. Noble metal nano‐systems, that is, gold and silver nanoparticles (NPs), have indeed unique physicochemical characteristics enabling them to deliver any pharmacological treatment in a more effective way within the central nervous system. This can potentially make NPs a new hope for reversing the actual therapeutic strategy based on slowing down an irreversible process into a more effective and permanent treatment.
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spelling pubmed-105277992023-10-02 Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments Scarpa, Edoardo Cascione, Mariafrancesca Griego, Anna Pellegrino, Paolo Moschetti, Giorgia De Matteis, Valeria Ibrain Reviews Neurodegenerative diseases (NDs) impose substantial medical and public health burdens on people worldwide and represent one of the major threats to human health. The prevalence of these age‐dependent disorders is dramatically increasing over time, a process intrinsically related to a constantly rising percentage of the elderly population in recent years. Among all the NDs, Alzheimer's and Parkinson's are considered the most debilitating as they cause memory and cognitive loss, as well as severely affecting basic physiological conditions such as the ability to move, speak, and breathe. There is an extreme need for new and more effective therapies to counteract these devastating diseases, as the available treatments are only able to slow down the pathogenic process without really stopping or resolving it. This review aims to elucidate the current nanotechnology‐based tools representing a future hope for NDs treatment. Noble metal nano‐systems, that is, gold and silver nanoparticles (NPs), have indeed unique physicochemical characteristics enabling them to deliver any pharmacological treatment in a more effective way within the central nervous system. This can potentially make NPs a new hope for reversing the actual therapeutic strategy based on slowing down an irreversible process into a more effective and permanent treatment. John Wiley and Sons Inc. 2023-08-14 /pmc/articles/PMC10527799/ /pubmed/37786760 http://dx.doi.org/10.1002/ibra.12126 Text en © 2023 The Authors. Ibrain published by Affiliated Hospital of Zunyi Medical University (AHZMU) and Wiley‐VCH GmbH. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Scarpa, Edoardo
Cascione, Mariafrancesca
Griego, Anna
Pellegrino, Paolo
Moschetti, Giorgia
De Matteis, Valeria
Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments
title Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments
title_full Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments
title_fullStr Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments
title_full_unstemmed Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments
title_short Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments
title_sort gold and silver nanoparticles in alzheimer's and parkinson's diagnostics and treatments
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527799/
https://www.ncbi.nlm.nih.gov/pubmed/37786760
http://dx.doi.org/10.1002/ibra.12126
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