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Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens

Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens. Local activation of these cells, either directly via pathogen recognition or indirectly via interaction with other activated immune cells and results in the release of pre-stored mediators in MC granules. The r...

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Autores principales: Mehrani, Yeganeh, Morovati, Solmaz, Tieu, Sophie, Karimi, Negar, Javadi, Helia, Vanderkamp, Sierra, Sarmadi, Soroush, Tajik, Tahmineh, Kakish, Julia E., Bridle, Byram W., Karimi, Khalil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528041/
https://www.ncbi.nlm.nih.gov/pubmed/37759494
http://dx.doi.org/10.3390/cells12182271
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author Mehrani, Yeganeh
Morovati, Solmaz
Tieu, Sophie
Karimi, Negar
Javadi, Helia
Vanderkamp, Sierra
Sarmadi, Soroush
Tajik, Tahmineh
Kakish, Julia E.
Bridle, Byram W.
Karimi, Khalil
author_facet Mehrani, Yeganeh
Morovati, Solmaz
Tieu, Sophie
Karimi, Negar
Javadi, Helia
Vanderkamp, Sierra
Sarmadi, Soroush
Tajik, Tahmineh
Kakish, Julia E.
Bridle, Byram W.
Karimi, Khalil
author_sort Mehrani, Yeganeh
collection PubMed
description Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens. Local activation of these cells, either directly via pathogen recognition or indirectly via interaction with other activated immune cells and results in the release of pre-stored mediators in MC granules. The release of these pre-stored mediators helps to enhance pathogen clearance. While MCs are well known for their protective role against parasites, there is also significant evidence in the literature demonstrating their ability to respond to viral, bacterial, and fungal infections. Vitamin D is a fat-soluble vitamin and hormone that plays a vital role in regulating calcium and phosphorus metabolism to maintain skeletal homeostasis. Emerging evidence suggests that vitamin D also has immunomodulatory properties on both the innate and adaptive immune systems, making it a critical regulator of immune homeostasis. Vitamin D binds to its receptor, called the vitamin D receptor (VDR), which is present in almost all immune system cells. The literature suggests that a vitamin D deficiency can activate MCs, and vitamin D is necessary for MC stabilization. This manuscript explores the potential of vitamin D to regulate MC activity and combat pathogens, with a focus on its ability to fight viruses.
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spelling pubmed-105280412023-09-28 Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens Mehrani, Yeganeh Morovati, Solmaz Tieu, Sophie Karimi, Negar Javadi, Helia Vanderkamp, Sierra Sarmadi, Soroush Tajik, Tahmineh Kakish, Julia E. Bridle, Byram W. Karimi, Khalil Cells Review Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens. Local activation of these cells, either directly via pathogen recognition or indirectly via interaction with other activated immune cells and results in the release of pre-stored mediators in MC granules. The release of these pre-stored mediators helps to enhance pathogen clearance. While MCs are well known for their protective role against parasites, there is also significant evidence in the literature demonstrating their ability to respond to viral, bacterial, and fungal infections. Vitamin D is a fat-soluble vitamin and hormone that plays a vital role in regulating calcium and phosphorus metabolism to maintain skeletal homeostasis. Emerging evidence suggests that vitamin D also has immunomodulatory properties on both the innate and adaptive immune systems, making it a critical regulator of immune homeostasis. Vitamin D binds to its receptor, called the vitamin D receptor (VDR), which is present in almost all immune system cells. The literature suggests that a vitamin D deficiency can activate MCs, and vitamin D is necessary for MC stabilization. This manuscript explores the potential of vitamin D to regulate MC activity and combat pathogens, with a focus on its ability to fight viruses. MDPI 2023-09-14 /pmc/articles/PMC10528041/ /pubmed/37759494 http://dx.doi.org/10.3390/cells12182271 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mehrani, Yeganeh
Morovati, Solmaz
Tieu, Sophie
Karimi, Negar
Javadi, Helia
Vanderkamp, Sierra
Sarmadi, Soroush
Tajik, Tahmineh
Kakish, Julia E.
Bridle, Byram W.
Karimi, Khalil
Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens
title Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens
title_full Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens
title_fullStr Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens
title_full_unstemmed Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens
title_short Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens
title_sort vitamin d influences the activity of mast cells in allergic manifestations and potentiates their effector functions against pathogens
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528041/
https://www.ncbi.nlm.nih.gov/pubmed/37759494
http://dx.doi.org/10.3390/cells12182271
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