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Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens
Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens. Local activation of these cells, either directly via pathogen recognition or indirectly via interaction with other activated immune cells and results in the release of pre-stored mediators in MC granules. The r...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528041/ https://www.ncbi.nlm.nih.gov/pubmed/37759494 http://dx.doi.org/10.3390/cells12182271 |
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author | Mehrani, Yeganeh Morovati, Solmaz Tieu, Sophie Karimi, Negar Javadi, Helia Vanderkamp, Sierra Sarmadi, Soroush Tajik, Tahmineh Kakish, Julia E. Bridle, Byram W. Karimi, Khalil |
author_facet | Mehrani, Yeganeh Morovati, Solmaz Tieu, Sophie Karimi, Negar Javadi, Helia Vanderkamp, Sierra Sarmadi, Soroush Tajik, Tahmineh Kakish, Julia E. Bridle, Byram W. Karimi, Khalil |
author_sort | Mehrani, Yeganeh |
collection | PubMed |
description | Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens. Local activation of these cells, either directly via pathogen recognition or indirectly via interaction with other activated immune cells and results in the release of pre-stored mediators in MC granules. The release of these pre-stored mediators helps to enhance pathogen clearance. While MCs are well known for their protective role against parasites, there is also significant evidence in the literature demonstrating their ability to respond to viral, bacterial, and fungal infections. Vitamin D is a fat-soluble vitamin and hormone that plays a vital role in regulating calcium and phosphorus metabolism to maintain skeletal homeostasis. Emerging evidence suggests that vitamin D also has immunomodulatory properties on both the innate and adaptive immune systems, making it a critical regulator of immune homeostasis. Vitamin D binds to its receptor, called the vitamin D receptor (VDR), which is present in almost all immune system cells. The literature suggests that a vitamin D deficiency can activate MCs, and vitamin D is necessary for MC stabilization. This manuscript explores the potential of vitamin D to regulate MC activity and combat pathogens, with a focus on its ability to fight viruses. |
format | Online Article Text |
id | pubmed-10528041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105280412023-09-28 Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens Mehrani, Yeganeh Morovati, Solmaz Tieu, Sophie Karimi, Negar Javadi, Helia Vanderkamp, Sierra Sarmadi, Soroush Tajik, Tahmineh Kakish, Julia E. Bridle, Byram W. Karimi, Khalil Cells Review Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens. Local activation of these cells, either directly via pathogen recognition or indirectly via interaction with other activated immune cells and results in the release of pre-stored mediators in MC granules. The release of these pre-stored mediators helps to enhance pathogen clearance. While MCs are well known for their protective role against parasites, there is also significant evidence in the literature demonstrating their ability to respond to viral, bacterial, and fungal infections. Vitamin D is a fat-soluble vitamin and hormone that plays a vital role in regulating calcium and phosphorus metabolism to maintain skeletal homeostasis. Emerging evidence suggests that vitamin D also has immunomodulatory properties on both the innate and adaptive immune systems, making it a critical regulator of immune homeostasis. Vitamin D binds to its receptor, called the vitamin D receptor (VDR), which is present in almost all immune system cells. The literature suggests that a vitamin D deficiency can activate MCs, and vitamin D is necessary for MC stabilization. This manuscript explores the potential of vitamin D to regulate MC activity and combat pathogens, with a focus on its ability to fight viruses. MDPI 2023-09-14 /pmc/articles/PMC10528041/ /pubmed/37759494 http://dx.doi.org/10.3390/cells12182271 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mehrani, Yeganeh Morovati, Solmaz Tieu, Sophie Karimi, Negar Javadi, Helia Vanderkamp, Sierra Sarmadi, Soroush Tajik, Tahmineh Kakish, Julia E. Bridle, Byram W. Karimi, Khalil Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens |
title | Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens |
title_full | Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens |
title_fullStr | Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens |
title_full_unstemmed | Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens |
title_short | Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens |
title_sort | vitamin d influences the activity of mast cells in allergic manifestations and potentiates their effector functions against pathogens |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528041/ https://www.ncbi.nlm.nih.gov/pubmed/37759494 http://dx.doi.org/10.3390/cells12182271 |
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