Cargando…

Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties

Cytochrome c (CytC) is a single-electron carrier between complex bc1 and cytochrome c-oxidase (CcO) in the electron transport chain (ETC). It is also known as a good radical scavenger but its participation in electron flow through the ETC makes it impossible to use CytC as a radical sensor. To solve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chertkova, Rita V., Oleynikov, Ilya P., Pakhomov, Alexey A., Sudakov, Roman V., Orlov, Victor N., Semenova, Marina A., Arutyunyan, Alexander M., Ptushenko, Vasily V., Kirpichnikov, Mikhail P., Dolgikh, Dmitry A., Vygodina, Tatiana V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528150/ https://www.ncbi.nlm.nih.gov/pubmed/37759538 http://dx.doi.org/10.3390/cells12182316

Ejemplares similares

Interaction of Amphipathic Peptide from Influenza Virus M1 Protein with Mitochondrial Cytochrome Oxidase
por: Oleynikov, Ilya P., et al.
Publicado: (2023)

Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells
por: Semenova, Marina A., et al.
Publicado: (2023)

Direct Interaction of Mitochondrial Cytochrome c Oxidase with Thyroid Hormones: Evidence for Two Binding Sites
por: Oleynikov, Ilya P., et al.
Publicado: (2022)

Interaction of Cytochrome C Oxidase with Steroid Hormones
por: Oleynikov, Ilya P., et al.
Publicado: (2020)

New insight into the mechanism of mitochondrial cytochrome c function
por: Chertkova, Rita V., et al.
Publicado: (2017)

Interaction of Terminal Oxidases with Amphipathic Molecules
por: Azarkina, Natalia V., et al.
Publicado: (2023)

The Kinetics of Amyloid Fibril Formation by de Novo Protein Albebetin and Its Mutant Variants
por: Balobanov, Vitalii, et al.
Publicado: (2020)

Kinetics and Energetics of Intramolecular Electron Transfer in Single-Point Labeled TUPS-Cytochrome c Derivatives
por: Khoroshyy, Petro, et al.
Publicado: (2021)

Multiple Mutations in the Non-Ordered Red Ω-Loop Enhance the Membrane-Permeabilizing and Peroxidase-like Activity of Cytochrome c
por: Chertkova, Rita V., et al.
Publicado: (2022)

GFP–Margatoxin, a Genetically Encoded Fluorescent Ligand to Probe Affinity of Kv1.3 Channel Blockers
por: Denisova, Kristina R., et al.
Publicado: (2022)

Spectrum of Light as a Determinant of Plant Functioning: A Historical Perspective
por: Ptushenko, Oxana S., et al.
Publicado: (2020)

The Photoprotective Protein PsbS from Green Microalga Lobosphaera incisa: The Amino Acid Sequence, 3D Structure and Probable pH-Sensitive Residues
por: Ptushenko, Vasily V., et al.
Publicado: (2023)

Direct Regulation of Cytochrome c Oxidase by Calcium Ions
por: Vygodina, Tatiana, et al.
Publicado: (2013)

A Review of the Dawn of Benchtop EPR Spectrometers—Innovation That Shaped the Future of This Technology
por: Ptushenko, Vasily V., et al.
Publicado: (2022)

Optimized Heterologous Expression and Efficient Purification of a New TRAIL-Based Antitumor Fusion Protein SRH–DR5-B with Dual VEGFR2 and DR5 Receptor Specificity
por: Yagolovich, Anne V., et al.
Publicado: (2022)

Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL
por: Artykov, Artem A., et al.
Publicado: (2021)

Corrigendum: Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL
por: Artykov, Artem A., et al.
Publicado: (2022)

Combination of TRAIL with Bortezomib Shifted Apoptotic Signaling from DR4 to DR5 Death Receptor by Selective Internalization and Degradation of DR4
por: Bychkov, Maxim L., et al.
Publicado: (2014)

Atto488-Agitoxin 2—A Fluorescent Ligand with Increased Selectivity for Kv1.3 Channel Binding Site
por: Denisova, Kristina R., et al.
Publicado: (2022)

Combining mKate2-Kv1.3 Channel and Atto488-Hongotoxin for the Studies of Peptide Pore Blockers on Living Eukaryotic Cells
por: Orlov, Nikita A., et al.
Publicado: (2022)

Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects
por: Rybchenko, Vladislav S., et al.
Publicado: (2023)

Epigallocatechin Gallate Affects the Structure of Chromatosomes, Nucleosomes and Their Complexes with PARP1
por: Andreeva, Tatiana V., et al.
Publicado: (2023)

Interactions of the Kv1.1 Channel with Peptide Pore Blockers: A Fluorescent Analysis on Mammalian Cells
por: Orlov, Nikita A., et al.
Publicado: (2023)

In Silico Prediction of Drug–Drug Interactions Mediated by Cytochrome P450 Isoforms
por: Dmitriev, Alexander V., et al.
Publicado: (2021)

Optimization of recombinant antibody production based on the vector design and the level of metabolites for generation of Ig- producing stable cell lines
por: Toporova, V. A., et al.
Publicado: (2023)

Superoxide Dismutase Activity in Male and Female Patients of Different Age with Moderate COVID-19
por: Semenova, N. V., et al.
Publicado: (2022)

Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile
por: Yagolovich, Anne V., et al.
Publicado: (2020)

Non-Functionalized Fullerenes and Endofullerenes in Aqueous Dispersions as Superoxide Scavengers
por: V. Mikheev, Ivan, et al.
Publicado: (2020)

The Phenomenon of Compensatory Cell Proliferation in Olfactory Epithelium in Fish Caused by Prolonged Exposure to Natural Odorants
por: Klimenkov, Igor V., et al.
Publicado: (2020)

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor
por: Lyukmanova, Ekaterina N., et al.
Publicado: (2016)

Engineering of Thermal Stability in a Cold-Active Oligo-1,6-Glucosidase from Exiguobacterium sibiricum with Unusual Amino Acid Content
por: Berlina, Yana Y., et al.
Publicado: (2021)

Pandemic Forecasting by Machine Learning in a Decision Support Problem
por: Sudakov, V. A., et al.
Publicado: (2023)

Structure and Dynamics of Compact Dinucleosomes: Analysis by Electron Microscopy and spFRET
por: Stefanova, Maria E., et al.
Publicado: (2023)

Rearrangement of Actin Microfilaments in the Development of Olfactory Receptor Cells in Fish
por: Klimenkov, Igor V., et al.
Publicado: (2018)

Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine
por: Boyko, Konstantin M., et al.
Publicado: (2020)

N-Terminal Tails of Histones H2A and H2B Differentially Affect Transcription by RNA Polymerase II In Vitro
por: Chang, Han-Wen, et al.
Publicado: (2022)

AgTx2-GFP, Fluorescent Blocker Targeting Pharmacologically Important K(v)1.x (x = 1, 3, 6) Channels
por: Primak, Alexandra L., et al.
Publicado: (2023)

Bacterial Synthesis and Purification of Normal and Mutant Forms of Human FGFR3 Transmembrane Segment
por: Goncharuk, S.A., et al.
Publicado: (2011)

DR5-Selective TRAIL Variant DR5-B Functionalized with Tumor-Penetrating iRGD Peptide for Enhanced Antitumor Activity against Glioblastoma
por: Yagolovich, Anne V., et al.
Publicado: (2022)

Bioengineered System for High Throughput Screening of Kv1 Ion Channel Blockers
por: Sharonov, George V., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uvlcv4bom9k66o5g21gnjgscrb