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Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome

OBJECTIVE: The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement. SUBJECTS AND METHODS: Twenty-five patients with Tur...

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Autores principales: Siqueira, Rodrigo de Azeredo, Carlos, Aluana Santana, d'Avila, Joana Costa, Moreno, Adalgiza Mafra, Alves, Estela Luz, de Farias, Maria Lucia Fleiuss, Mendonça, Laura Maria C., Guimarães, Marilia Martins
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528628/
https://www.ncbi.nlm.nih.gov/pubmed/34033286
http://dx.doi.org/10.20945/2359-3997000000287
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author Siqueira, Rodrigo de Azeredo
Carlos, Aluana Santana
d'Avila, Joana Costa
Moreno, Adalgiza Mafra
Alves, Estela Luz
de Farias, Maria Lucia Fleiuss
Mendonça, Laura Maria C.
Guimarães, Marilia Martins
author_facet Siqueira, Rodrigo de Azeredo
Carlos, Aluana Santana
d'Avila, Joana Costa
Moreno, Adalgiza Mafra
Alves, Estela Luz
de Farias, Maria Lucia Fleiuss
Mendonça, Laura Maria C.
Guimarães, Marilia Martins
author_sort Siqueira, Rodrigo de Azeredo
collection PubMed
description OBJECTIVE: The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement. SUBJECTS AND METHODS: Twenty-five patients with Turner's syndrome receiving oral or transdermal estrogen replacement were evaluated for body mass index, waist-to-hip and waist-to-height ratios, fasting glycemia, insulin, body composition (dual-energy X-ray absorptiometry), and postprandial lipid metabolism. For statistical analysis, we used parametric tests to compare numeric variables between the two subgroups. RESULTS: We observed no difference in postprandial triglyceride levels between patients receiving oral versus transdermal hormone replacement therapy. The postprandial triglycerides increment correlated positively with the percentage of total fat mass (p=0.02) and android fat mass (p=0.02) in the transdermal group. In the oral estrogen group, a positive correlation was observed between the increment in postprandial triglycerides and waist-to-hip (p=0.15) and waist-to-height (p=0.009) ratios. No association was observed between the estrogen replacement route and insulin resistance evaluated by the homeostatic model assessment–insulin resistance (HOMA-IR) index (p=0.19 and p=0.65 for the oral and transdermal groups, respectively). CONCLUSION: We concluded that body composition and anthropometric characteristics possibly affect the extent of postprandial lipemia independently from the route of estrogen replacement.
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spelling pubmed-105286282023-09-28 Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome Siqueira, Rodrigo de Azeredo Carlos, Aluana Santana d'Avila, Joana Costa Moreno, Adalgiza Mafra Alves, Estela Luz de Farias, Maria Lucia Fleiuss Mendonça, Laura Maria C. Guimarães, Marilia Martins Arch Endocrinol Metab Original Article OBJECTIVE: The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement. SUBJECTS AND METHODS: Twenty-five patients with Turner's syndrome receiving oral or transdermal estrogen replacement were evaluated for body mass index, waist-to-hip and waist-to-height ratios, fasting glycemia, insulin, body composition (dual-energy X-ray absorptiometry), and postprandial lipid metabolism. For statistical analysis, we used parametric tests to compare numeric variables between the two subgroups. RESULTS: We observed no difference in postprandial triglyceride levels between patients receiving oral versus transdermal hormone replacement therapy. The postprandial triglycerides increment correlated positively with the percentage of total fat mass (p=0.02) and android fat mass (p=0.02) in the transdermal group. In the oral estrogen group, a positive correlation was observed between the increment in postprandial triglycerides and waist-to-hip (p=0.15) and waist-to-height (p=0.009) ratios. No association was observed between the estrogen replacement route and insulin resistance evaluated by the homeostatic model assessment–insulin resistance (HOMA-IR) index (p=0.19 and p=0.65 for the oral and transdermal groups, respectively). CONCLUSION: We concluded that body composition and anthropometric characteristics possibly affect the extent of postprandial lipemia independently from the route of estrogen replacement. Sociedade Brasileira de Endocrinologia e Metabologia 2020-08-24 /pmc/articles/PMC10528628/ /pubmed/34033286 http://dx.doi.org/10.20945/2359-3997000000287 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Siqueira, Rodrigo de Azeredo
Carlos, Aluana Santana
d'Avila, Joana Costa
Moreno, Adalgiza Mafra
Alves, Estela Luz
de Farias, Maria Lucia Fleiuss
Mendonça, Laura Maria C.
Guimarães, Marilia Martins
Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
title Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
title_full Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
title_fullStr Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
title_full_unstemmed Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
title_short Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
title_sort body composition, but not insulin resistance, influences postprandial lipemia in patients with turner's syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528628/
https://www.ncbi.nlm.nih.gov/pubmed/34033286
http://dx.doi.org/10.20945/2359-3997000000287
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