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COVID-19 and obesity: the meeting of two pandemics

COVID-19 and obesity are two pandemic diseases that the world is currently facing. Both activate the immune system and mediate inflammation. A sequence of disease phases in patients with severe COVID-19 results in a cytokine storm, which amplifies the subclinical inflammation that already exists in...

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Detalles Bibliográficos
Autores principales: Brandão, Simone Cristina Soares, Godoi, Emmanuelle Tenório Albuquerque Madruga, Cordeiro, Lúcia Helena de Oliveira, Bezerra, Camila Silva, Ramos, Júlia de Oliveira Xavier, de Arruda, Gustavo Freitas Alves, Lins, Esdras Marques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528705/
https://www.ncbi.nlm.nih.gov/pubmed/33320454
http://dx.doi.org/10.20945/2359-3997000000318
Descripción
Sumario:COVID-19 and obesity are two pandemic diseases that the world is currently facing. Both activate the immune system and mediate inflammation. A sequence of disease phases in patients with severe COVID-19 results in a cytokine storm, which amplifies the subclinical inflammation that already exists in patients with obesity. Pro-inflammatory cytokines and chemotactic factors increase insulin resistance in obesity. Therefore, a greater systemic inflammatory response is establishe, along with an increased risk of thrombotic phenomena and hyperglycemic conditions. These changes further impair pulmonary, cardiac, hepatic, and renal functions, in addition to hindering glycemic control in people with diabetes and pre-diabetes. This review explains the pathophysiological mechanisms of these two pandemic diseases, provides a deeper understanding of this harmful interaction and lists possible therapeutic strategies for this risk group.