A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes

Reactive microglia are observed with aging and in Lewy body disorders, including within the olfactory bulb of men with Parkinson’s disease. However, the functional impact of microglia in these disorders is still debated. Resetting these reactive cells by a brief dietary pulse of the colony-stimulati...

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Detalles Bibliográficos
Autores principales: Bhatia, Tarun N., Jamenis, Anuj S., Abbas, Muslim, Clark, Rachel N., Miner, Kristin M., Chandwani, Manisha N., Kim, Roxanne E., Hilinski, William, O’Donnell, Lauren A., Luk, Kelvin C., Shi, Yejie, Hu, Xiaoming, Chen, Jun, Brodsky, Jeffrey L., Leak, Rehana K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528721/
https://www.ncbi.nlm.nih.gov/pubmed/37315905
http://dx.doi.org/10.1016/j.nbd.2023.106196

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