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Application and progress of three‐dimensional bioprinting in spinal cord injury
Spinal cord injury (SCI) is a central nervous system disorder that can lead to sensory and motor dysfunction, which can seriously increase pressure and economic burden on families and societies. The current SCI treatment is mainly to stabilize the spine, prevent secondary damage, and control inflamm...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528796/ https://www.ncbi.nlm.nih.gov/pubmed/37786558 http://dx.doi.org/10.1002/ibra.12005 |
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author | Xia, Qiu‐Qiu Yuan, Hao Wang, Ting‐Hua Xiong, Liu‐Lin Xin, Zhi‐Jun |
author_facet | Xia, Qiu‐Qiu Yuan, Hao Wang, Ting‐Hua Xiong, Liu‐Lin Xin, Zhi‐Jun |
author_sort | Xia, Qiu‐Qiu |
collection | PubMed |
description | Spinal cord injury (SCI) is a central nervous system disorder that can lead to sensory and motor dysfunction, which can seriously increase pressure and economic burden on families and societies. The current SCI treatment is mainly to stabilize the spine, prevent secondary damage, and control inflammation. Drug treatment is limited to early, large‐scale use of steroids to reduce the effects of edema after SCI. In short, there is no direct treatment for SCI. Recent 3D bioprinting development provides a new solution for SCI treatment: a series of spinal cord bionic scaffolds are being developed to improve spinal cord function after injury. This paper reviews the pathophysiological characteristics of SCI, current treatment methods, and the progress of 3D bioprinting in SCI. Finally, its challenges and prospects in SCI treatment are summarized. |
format | Online Article Text |
id | pubmed-10528796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105287962023-10-02 Application and progress of three‐dimensional bioprinting in spinal cord injury Xia, Qiu‐Qiu Yuan, Hao Wang, Ting‐Hua Xiong, Liu‐Lin Xin, Zhi‐Jun Ibrain Reviews Spinal cord injury (SCI) is a central nervous system disorder that can lead to sensory and motor dysfunction, which can seriously increase pressure and economic burden on families and societies. The current SCI treatment is mainly to stabilize the spine, prevent secondary damage, and control inflammation. Drug treatment is limited to early, large‐scale use of steroids to reduce the effects of edema after SCI. In short, there is no direct treatment for SCI. Recent 3D bioprinting development provides a new solution for SCI treatment: a series of spinal cord bionic scaffolds are being developed to improve spinal cord function after injury. This paper reviews the pathophysiological characteristics of SCI, current treatment methods, and the progress of 3D bioprinting in SCI. Finally, its challenges and prospects in SCI treatment are summarized. John Wiley and Sons Inc. 2021-12-11 /pmc/articles/PMC10528796/ /pubmed/37786558 http://dx.doi.org/10.1002/ibra.12005 Text en © 2021 The Authors. Ibrain published by Affiliated Hospital of Zunyi Medical University and Wiley-VCH GmbH. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Xia, Qiu‐Qiu Yuan, Hao Wang, Ting‐Hua Xiong, Liu‐Lin Xin, Zhi‐Jun Application and progress of three‐dimensional bioprinting in spinal cord injury |
title | Application and progress of three‐dimensional bioprinting in spinal cord injury |
title_full | Application and progress of three‐dimensional bioprinting in spinal cord injury |
title_fullStr | Application and progress of three‐dimensional bioprinting in spinal cord injury |
title_full_unstemmed | Application and progress of three‐dimensional bioprinting in spinal cord injury |
title_short | Application and progress of three‐dimensional bioprinting in spinal cord injury |
title_sort | application and progress of three‐dimensional bioprinting in spinal cord injury |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528796/ https://www.ncbi.nlm.nih.gov/pubmed/37786558 http://dx.doi.org/10.1002/ibra.12005 |
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