Cargando…

Application and progress of three‐dimensional bioprinting in spinal cord injury

Spinal cord injury (SCI) is a central nervous system disorder that can lead to sensory and motor dysfunction, which can seriously increase pressure and economic burden on families and societies. The current SCI treatment is mainly to stabilize the spine, prevent secondary damage, and control inflamm...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Qiu‐Qiu, Yuan, Hao, Wang, Ting‐Hua, Xiong, Liu‐Lin, Xin, Zhi‐Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528796/
https://www.ncbi.nlm.nih.gov/pubmed/37786558
http://dx.doi.org/10.1002/ibra.12005
_version_ 1785111313016422400
author Xia, Qiu‐Qiu
Yuan, Hao
Wang, Ting‐Hua
Xiong, Liu‐Lin
Xin, Zhi‐Jun
author_facet Xia, Qiu‐Qiu
Yuan, Hao
Wang, Ting‐Hua
Xiong, Liu‐Lin
Xin, Zhi‐Jun
author_sort Xia, Qiu‐Qiu
collection PubMed
description Spinal cord injury (SCI) is a central nervous system disorder that can lead to sensory and motor dysfunction, which can seriously increase pressure and economic burden on families and societies. The current SCI treatment is mainly to stabilize the spine, prevent secondary damage, and control inflammation. Drug treatment is limited to early, large‐scale use of steroids to reduce the effects of edema after SCI. In short, there is no direct treatment for SCI. Recent 3D bioprinting development provides a new solution for SCI treatment: a series of spinal cord bionic scaffolds are being developed to improve spinal cord function after injury. This paper reviews the pathophysiological characteristics of SCI, current treatment methods, and the progress of 3D bioprinting in SCI. Finally, its challenges and prospects in SCI treatment are summarized.
format Online
Article
Text
id pubmed-10528796
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-105287962023-10-02 Application and progress of three‐dimensional bioprinting in spinal cord injury Xia, Qiu‐Qiu Yuan, Hao Wang, Ting‐Hua Xiong, Liu‐Lin Xin, Zhi‐Jun Ibrain Reviews Spinal cord injury (SCI) is a central nervous system disorder that can lead to sensory and motor dysfunction, which can seriously increase pressure and economic burden on families and societies. The current SCI treatment is mainly to stabilize the spine, prevent secondary damage, and control inflammation. Drug treatment is limited to early, large‐scale use of steroids to reduce the effects of edema after SCI. In short, there is no direct treatment for SCI. Recent 3D bioprinting development provides a new solution for SCI treatment: a series of spinal cord bionic scaffolds are being developed to improve spinal cord function after injury. This paper reviews the pathophysiological characteristics of SCI, current treatment methods, and the progress of 3D bioprinting in SCI. Finally, its challenges and prospects in SCI treatment are summarized. John Wiley and Sons Inc. 2021-12-11 /pmc/articles/PMC10528796/ /pubmed/37786558 http://dx.doi.org/10.1002/ibra.12005 Text en © 2021 The Authors. Ibrain published by Affiliated Hospital of Zunyi Medical University and Wiley-VCH GmbH. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Xia, Qiu‐Qiu
Yuan, Hao
Wang, Ting‐Hua
Xiong, Liu‐Lin
Xin, Zhi‐Jun
Application and progress of three‐dimensional bioprinting in spinal cord injury
title Application and progress of three‐dimensional bioprinting in spinal cord injury
title_full Application and progress of three‐dimensional bioprinting in spinal cord injury
title_fullStr Application and progress of three‐dimensional bioprinting in spinal cord injury
title_full_unstemmed Application and progress of three‐dimensional bioprinting in spinal cord injury
title_short Application and progress of three‐dimensional bioprinting in spinal cord injury
title_sort application and progress of three‐dimensional bioprinting in spinal cord injury
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528796/
https://www.ncbi.nlm.nih.gov/pubmed/37786558
http://dx.doi.org/10.1002/ibra.12005
work_keys_str_mv AT xiaqiuqiu applicationandprogressofthreedimensionalbioprintinginspinalcordinjury
AT yuanhao applicationandprogressofthreedimensionalbioprintinginspinalcordinjury
AT wangtinghua applicationandprogressofthreedimensionalbioprintinginspinalcordinjury
AT xiongliulin applicationandprogressofthreedimensionalbioprintinginspinalcordinjury
AT xinzhijun applicationandprogressofthreedimensionalbioprintinginspinalcordinjury