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Changes in microglia during drug treatment of stroke

Microglia are the main immune cells in the brain and the first defense barrier of the nervous system. Microglia play a complex role in the process of stroke. A growing number of studies focus on the mechanism of action of drugs functions and how to regulate microglia. Therefore, we talk about the pa...

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Detalles Bibliográficos
Autores principales: Zhang, Ling‐Jing, Zhou, Hong‐Su, Wang, Shi‐Ya, Guan, Yi‐Huan, Zhang, Chao, Fang, De‐Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528798/
https://www.ncbi.nlm.nih.gov/pubmed/37786889
http://dx.doi.org/10.1002/ibra.12037
Descripción
Sumario:Microglia are the main immune cells in the brain and the first defense barrier of the nervous system. Microglia play a complex role in the process of stroke. A growing number of studies focus on the mechanism of action of drugs functions and how to regulate microglia. Therefore, we talk about the pathophysiological mechanisms of stroke and elaborate on the microglia signaling pathways of drug action in stroke models and how these drugs play a role in stroke treatment in this review. Understanding how drugs modulate proinflammatory and anti‐inflammatory responses of microglia may be critical to implementing therapeutic strategies using immune interventions in stroke.