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Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides

Thermoresponsive Pluronic® F127 (PL) gels in water were investigated through rheological tests in different shear conditions. The gel strength was tuned with the addition of 1% polysaccharide solution. In the presence of xanthan gum (XG), the viscoelastic behavior of PL-based hydrogels was improved...

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Autores principales: Lupu, Alexandra, Gradinaru, Luiza Madalina, Rusu, Daniela, Bercea, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528848/
https://www.ncbi.nlm.nih.gov/pubmed/37754400
http://dx.doi.org/10.3390/gels9090719
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author Lupu, Alexandra
Gradinaru, Luiza Madalina
Rusu, Daniela
Bercea, Maria
author_facet Lupu, Alexandra
Gradinaru, Luiza Madalina
Rusu, Daniela
Bercea, Maria
author_sort Lupu, Alexandra
collection PubMed
description Thermoresponsive Pluronic® F127 (PL) gels in water were investigated through rheological tests in different shear conditions. The gel strength was tuned with the addition of 1% polysaccharide solution. In the presence of xanthan gum (XG), the viscoelastic behavior of PL-based hydrogels was improved in aqueous environment, but the rheological behavior was less changed with the addition of XG in PBS solutions, whereas in the presence of 0.1 M NaCl, the viscoelastic parameters decreased. PL micellar networks exhibited a self-healing ability, recovering their initial structure after applying cycles of high strain. The rheological characteristics of the PL hydrogel changed with the addition of 1% polysaccharides (xanthan gum, alginate, κ-carrageenan, gellan, or chitosan). PL/polysaccharide systems form temperature-responsive hydrogels with shear thinning behavior, yield stress, and self-healing ability, being considered a versatile platform for injectable biomaterials or bioinks. Thus, in the presence of xanthan gum in aqueous medium, the gel strength was improved after applying a high strain (the values of elastic modulus increased). The other investigated natural polymers induced specific self-healing behaviors. Good performances were observed with the addition of gellan gum, alginate, and κ-carrageenan, but for high values of strain, the ability to recover the initial structure decreased. A modest self-healing behavior was observed in the presence of chitosan and xanthan gum dissolved in NaCl solution.
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spelling pubmed-105288482023-09-28 Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides Lupu, Alexandra Gradinaru, Luiza Madalina Rusu, Daniela Bercea, Maria Gels Article Thermoresponsive Pluronic® F127 (PL) gels in water were investigated through rheological tests in different shear conditions. The gel strength was tuned with the addition of 1% polysaccharide solution. In the presence of xanthan gum (XG), the viscoelastic behavior of PL-based hydrogels was improved in aqueous environment, but the rheological behavior was less changed with the addition of XG in PBS solutions, whereas in the presence of 0.1 M NaCl, the viscoelastic parameters decreased. PL micellar networks exhibited a self-healing ability, recovering their initial structure after applying cycles of high strain. The rheological characteristics of the PL hydrogel changed with the addition of 1% polysaccharides (xanthan gum, alginate, κ-carrageenan, gellan, or chitosan). PL/polysaccharide systems form temperature-responsive hydrogels with shear thinning behavior, yield stress, and self-healing ability, being considered a versatile platform for injectable biomaterials or bioinks. Thus, in the presence of xanthan gum in aqueous medium, the gel strength was improved after applying a high strain (the values of elastic modulus increased). The other investigated natural polymers induced specific self-healing behaviors. Good performances were observed with the addition of gellan gum, alginate, and κ-carrageenan, but for high values of strain, the ability to recover the initial structure decreased. A modest self-healing behavior was observed in the presence of chitosan and xanthan gum dissolved in NaCl solution. MDPI 2023-09-05 /pmc/articles/PMC10528848/ /pubmed/37754400 http://dx.doi.org/10.3390/gels9090719 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lupu, Alexandra
Gradinaru, Luiza Madalina
Rusu, Daniela
Bercea, Maria
Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides
title Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides
title_full Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides
title_fullStr Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides
title_full_unstemmed Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides
title_short Self-Healing of Pluronic® F127 Hydrogels in the Presence of Various Polysaccharides
title_sort self-healing of pluronic® f127 hydrogels in the presence of various polysaccharides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528848/
https://www.ncbi.nlm.nih.gov/pubmed/37754400
http://dx.doi.org/10.3390/gels9090719
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