Role of Na(V)1.6-mediated persistent sodium current and bursting-pacemaker properties in breathing rhythm generation

Inspiration is the inexorable active phase of breathing. The brainstem preBötzinger complex (preBötC) gives rise to inspiratory neural rhythm, but its underlying cellular and ionic bases remain unclear. The long-standing “pacemaker hypothesis” posits that the persistent Na(+) current (I(NaP)) that g...

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Detalles Bibliográficos
Autores principales: da Silva, Carlos A., Grover, Cameron J., Picardo, Maria Cristina D., Del Negro, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528911/
https://www.ncbi.nlm.nih.gov/pubmed/37590134
http://dx.doi.org/10.1016/j.celrep.2023.113000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528911/
https://www.ncbi.nlm.nih.gov/pubmed/37590134
http://dx.doi.org/10.1016/j.celrep.2023.113000

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