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Role of Na(V)1.6-mediated persistent sodium current and bursting-pacemaker properties in breathing rhythm generation
Inspiration is the inexorable active phase of breathing. The brainstem preBötzinger complex (preBötC) gives rise to inspiratory neural rhythm, but its underlying cellular and ionic bases remain unclear. The long-standing “pacemaker hypothesis” posits that the persistent Na(+) current (I(NaP)) that g...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528911/ https://www.ncbi.nlm.nih.gov/pubmed/37590134 http://dx.doi.org/10.1016/j.celrep.2023.113000 |