Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder, but new therapies have been impeded by a lack of understanding of the pathological mechanisms. Tuberous sclerosis complex (TSC) and fragile X syndrome are associated with alterations in the mechanistic target of rapamy...

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Detalles Bibliográficos
Autores principales: Winden, Kellen D., Pham, Truc T., Teaney, Nicole A., Ruiz, Juan, Chen, Ryan, Chen, Cidi, Sahin, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529098/
https://www.ncbi.nlm.nih.gov/pubmed/37494191
http://dx.doi.org/10.1016/j.celrep.2023.112838

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