Cargando…

A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma

Phaeochromocytomas (PC) and sympathetic paragangliomas (PGL) are potentially malignant tumours arising from the adrenal medulla (PC) or elsewhere in the sympathetic nervous system (PGL). These tumours usually secrete catecholamines and are associated with significant morbidity and mortality, so accu...

Descripción completa

Detalles Bibliográficos
Autor principal: Boot, Christopher S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529273/
https://www.ncbi.nlm.nih.gov/pubmed/37761307
http://dx.doi.org/10.3390/diagnostics13182940
_version_ 1785111367195295744
author Boot, Christopher S.
author_facet Boot, Christopher S.
author_sort Boot, Christopher S.
collection PubMed
description Phaeochromocytomas (PC) and sympathetic paragangliomas (PGL) are potentially malignant tumours arising from the adrenal medulla (PC) or elsewhere in the sympathetic nervous system (PGL). These tumours usually secrete catecholamines and are associated with significant morbidity and mortality, so accurate and timely diagnosis is essential. The initial diagnosis of phaeochromocytoma/paraganglioma (PPGL) is often dependent on biochemical testing. There is a range of pre-analytical, analytical and post-analytical factors influencing the analytical and diagnostic performance of biochemical tests for PPGL. Pre-analytical factors include patient preparation, sample handling and choice of test. Analytical factors include choice of methodology and the potential for analytical interference from medications and other compounds. Important factors in the post-analytical phase include provision of appropriate reference ranges, an understanding of the potential effects of various medications on metanephrine concentrations in urine and plasma and a consideration of PPGL prevalence in the patient population being tested. This article reviews these pre-analytical, analytical and post-analytical factors that must be understood in order to provide effective laboratory services for biochemical testing in the diagnosis of PPGL.
format Online
Article
Text
id pubmed-10529273
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105292732023-09-28 A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma Boot, Christopher S. Diagnostics (Basel) Review Phaeochromocytomas (PC) and sympathetic paragangliomas (PGL) are potentially malignant tumours arising from the adrenal medulla (PC) or elsewhere in the sympathetic nervous system (PGL). These tumours usually secrete catecholamines and are associated with significant morbidity and mortality, so accurate and timely diagnosis is essential. The initial diagnosis of phaeochromocytoma/paraganglioma (PPGL) is often dependent on biochemical testing. There is a range of pre-analytical, analytical and post-analytical factors influencing the analytical and diagnostic performance of biochemical tests for PPGL. Pre-analytical factors include patient preparation, sample handling and choice of test. Analytical factors include choice of methodology and the potential for analytical interference from medications and other compounds. Important factors in the post-analytical phase include provision of appropriate reference ranges, an understanding of the potential effects of various medications on metanephrine concentrations in urine and plasma and a consideration of PPGL prevalence in the patient population being tested. This article reviews these pre-analytical, analytical and post-analytical factors that must be understood in order to provide effective laboratory services for biochemical testing in the diagnosis of PPGL. MDPI 2023-09-13 /pmc/articles/PMC10529273/ /pubmed/37761307 http://dx.doi.org/10.3390/diagnostics13182940 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boot, Christopher S.
A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma
title A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma
title_full A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma
title_fullStr A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma
title_full_unstemmed A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma
title_short A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma
title_sort laboratory medicine perspective on the investigation of phaeochromocytoma and paraganglioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529273/
https://www.ncbi.nlm.nih.gov/pubmed/37761307
http://dx.doi.org/10.3390/diagnostics13182940
work_keys_str_mv AT bootchristophers alaboratorymedicineperspectiveontheinvestigationofphaeochromocytomaandparaganglioma
AT bootchristophers laboratorymedicineperspectiveontheinvestigationofphaeochromocytomaandparaganglioma