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A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma
Phaeochromocytomas (PC) and sympathetic paragangliomas (PGL) are potentially malignant tumours arising from the adrenal medulla (PC) or elsewhere in the sympathetic nervous system (PGL). These tumours usually secrete catecholamines and are associated with significant morbidity and mortality, so accu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529273/ https://www.ncbi.nlm.nih.gov/pubmed/37761307 http://dx.doi.org/10.3390/diagnostics13182940 |
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author | Boot, Christopher S. |
author_facet | Boot, Christopher S. |
author_sort | Boot, Christopher S. |
collection | PubMed |
description | Phaeochromocytomas (PC) and sympathetic paragangliomas (PGL) are potentially malignant tumours arising from the adrenal medulla (PC) or elsewhere in the sympathetic nervous system (PGL). These tumours usually secrete catecholamines and are associated with significant morbidity and mortality, so accurate and timely diagnosis is essential. The initial diagnosis of phaeochromocytoma/paraganglioma (PPGL) is often dependent on biochemical testing. There is a range of pre-analytical, analytical and post-analytical factors influencing the analytical and diagnostic performance of biochemical tests for PPGL. Pre-analytical factors include patient preparation, sample handling and choice of test. Analytical factors include choice of methodology and the potential for analytical interference from medications and other compounds. Important factors in the post-analytical phase include provision of appropriate reference ranges, an understanding of the potential effects of various medications on metanephrine concentrations in urine and plasma and a consideration of PPGL prevalence in the patient population being tested. This article reviews these pre-analytical, analytical and post-analytical factors that must be understood in order to provide effective laboratory services for biochemical testing in the diagnosis of PPGL. |
format | Online Article Text |
id | pubmed-10529273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105292732023-09-28 A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma Boot, Christopher S. Diagnostics (Basel) Review Phaeochromocytomas (PC) and sympathetic paragangliomas (PGL) are potentially malignant tumours arising from the adrenal medulla (PC) or elsewhere in the sympathetic nervous system (PGL). These tumours usually secrete catecholamines and are associated with significant morbidity and mortality, so accurate and timely diagnosis is essential. The initial diagnosis of phaeochromocytoma/paraganglioma (PPGL) is often dependent on biochemical testing. There is a range of pre-analytical, analytical and post-analytical factors influencing the analytical and diagnostic performance of biochemical tests for PPGL. Pre-analytical factors include patient preparation, sample handling and choice of test. Analytical factors include choice of methodology and the potential for analytical interference from medications and other compounds. Important factors in the post-analytical phase include provision of appropriate reference ranges, an understanding of the potential effects of various medications on metanephrine concentrations in urine and plasma and a consideration of PPGL prevalence in the patient population being tested. This article reviews these pre-analytical, analytical and post-analytical factors that must be understood in order to provide effective laboratory services for biochemical testing in the diagnosis of PPGL. MDPI 2023-09-13 /pmc/articles/PMC10529273/ /pubmed/37761307 http://dx.doi.org/10.3390/diagnostics13182940 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boot, Christopher S. A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma |
title | A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma |
title_full | A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma |
title_fullStr | A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma |
title_full_unstemmed | A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma |
title_short | A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma |
title_sort | laboratory medicine perspective on the investigation of phaeochromocytoma and paraganglioma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529273/ https://www.ncbi.nlm.nih.gov/pubmed/37761307 http://dx.doi.org/10.3390/diagnostics13182940 |
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