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Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice
Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus responsible for epidemics of neurological disease across the Americas. Low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) is a recently reported entry receptor for VEEV. Here, using wild-type and Ldlrad3-de...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529316/ https://www.ncbi.nlm.nih.gov/pubmed/37556325 http://dx.doi.org/10.1016/j.celrep.2023.112946 |
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author | Kafai, Natasha M. Janova, Hana Cain, Matthew D. Alippe, Yael Muraro, Stefanie Sariol, Alan Elam-Noll, Michelle Klein, Robyn S. Diamond, Michael S. |
author_facet | Kafai, Natasha M. Janova, Hana Cain, Matthew D. Alippe, Yael Muraro, Stefanie Sariol, Alan Elam-Noll, Michelle Klein, Robyn S. Diamond, Michael S. |
author_sort | Kafai, Natasha M. |
collection | PubMed |
description | Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus responsible for epidemics of neurological disease across the Americas. Low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) is a recently reported entry receptor for VEEV. Here, using wild-type and Ldlrad3-deficient mice, we define a critical role for LDLRAD3 in controlling steps in VEEV infection, pathogenesis, and neuro-tropism. Our analysis shows that LDLRAD3 is required for efficient VEEV infection and pathogenesis prior to and after central nervous system invasion. Ldlrad3-deficient mice survive intranasal and intracranial VEEV inoculation and show reduced infection of neurons in different brain regions. As LDLRAD3 is a determinant of pathogenesis and an entry receptor required for VEEV infection of neurons of the brain, receptor-targeted therapies may hold promise as countermeasures. |
format | Online Article Text |
id | pubmed-10529316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-105293162023-09-27 Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice Kafai, Natasha M. Janova, Hana Cain, Matthew D. Alippe, Yael Muraro, Stefanie Sariol, Alan Elam-Noll, Michelle Klein, Robyn S. Diamond, Michael S. Cell Rep Article Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus responsible for epidemics of neurological disease across the Americas. Low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) is a recently reported entry receptor for VEEV. Here, using wild-type and Ldlrad3-deficient mice, we define a critical role for LDLRAD3 in controlling steps in VEEV infection, pathogenesis, and neuro-tropism. Our analysis shows that LDLRAD3 is required for efficient VEEV infection and pathogenesis prior to and after central nervous system invasion. Ldlrad3-deficient mice survive intranasal and intracranial VEEV inoculation and show reduced infection of neurons in different brain regions. As LDLRAD3 is a determinant of pathogenesis and an entry receptor required for VEEV infection of neurons of the brain, receptor-targeted therapies may hold promise as countermeasures. 2023-08-29 2023-08-08 /pmc/articles/PMC10529316/ /pubmed/37556325 http://dx.doi.org/10.1016/j.celrep.2023.112946 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Kafai, Natasha M. Janova, Hana Cain, Matthew D. Alippe, Yael Muraro, Stefanie Sariol, Alan Elam-Noll, Michelle Klein, Robyn S. Diamond, Michael S. Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice |
title | Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice |
title_full | Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice |
title_fullStr | Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice |
title_full_unstemmed | Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice |
title_short | Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice |
title_sort | entry receptor ldlrad3 is required for venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529316/ https://www.ncbi.nlm.nih.gov/pubmed/37556325 http://dx.doi.org/10.1016/j.celrep.2023.112946 |
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