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Tumor Characteristics Associated with Axillary Nodal Positivity in Triple Negative Breast Cancer

Larger-size primary tumors are correlated with axillary metastases and worse outcomes. We evaluated the relationships among tumor size, location, and distance to nipple relative to axillary node metastases in triple-negative breast cancer (TNBC) patients, as well as the predictive capacity of imagin...

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Autores principales: Chintapally, Neha, Englander, Katherine, Gallagher, Julia, Elleson, Kelly, Sun, Weihong, Whiting, Junmin, Laronga, Christine, Lee, Marie Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529347/
https://www.ncbi.nlm.nih.gov/pubmed/37754314
http://dx.doi.org/10.3390/diseases11030118
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author Chintapally, Neha
Englander, Katherine
Gallagher, Julia
Elleson, Kelly
Sun, Weihong
Whiting, Junmin
Laronga, Christine
Lee, Marie Catherine
author_facet Chintapally, Neha
Englander, Katherine
Gallagher, Julia
Elleson, Kelly
Sun, Weihong
Whiting, Junmin
Laronga, Christine
Lee, Marie Catherine
author_sort Chintapally, Neha
collection PubMed
description Larger-size primary tumors are correlated with axillary metastases and worse outcomes. We evaluated the relationships among tumor size, location, and distance to nipple relative to axillary node metastases in triple-negative breast cancer (TNBC) patients, as well as the predictive capacity of imaging. We conducted a single-institution, retrospective chart review of stage I–III TNBC patients diagnosed from 1998 to 2019 who underwent upfront surgery. Seventy-three patients had a mean tumor size of 20 mm (range 1–53 mm). All patients were clinically node negative. Thirty-two patients were sentinel lymph node positive, of whom 25 underwent axillary lymph node dissection. Larger tumor size was associated with positive nodes (p < 0.001): the mean tumor size was 14.30 mm in node negative patients and 27.31 mm in node positive patients. Tumor to nipple distance was shorter in node positive patients (51.0 mm) vs. node negative patients (73.3 mm) (p = 0.005). The presence of LVI was associated with nodal positivity (p < 0.001). Tumor quadrant was not associated with nodal metastasis. Ultrasound yielded the largest number of suspicious findings (21/49), with sensitivity of 0.25 and specificity of 0.40. On univariate analysis, age younger than 60 at diagnosis was also associated with nodal positivity (p < 0.002). Comparative analyses with other subtypes may identify biologic determinants.
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spelling pubmed-105293472023-09-28 Tumor Characteristics Associated with Axillary Nodal Positivity in Triple Negative Breast Cancer Chintapally, Neha Englander, Katherine Gallagher, Julia Elleson, Kelly Sun, Weihong Whiting, Junmin Laronga, Christine Lee, Marie Catherine Diseases Article Larger-size primary tumors are correlated with axillary metastases and worse outcomes. We evaluated the relationships among tumor size, location, and distance to nipple relative to axillary node metastases in triple-negative breast cancer (TNBC) patients, as well as the predictive capacity of imaging. We conducted a single-institution, retrospective chart review of stage I–III TNBC patients diagnosed from 1998 to 2019 who underwent upfront surgery. Seventy-three patients had a mean tumor size of 20 mm (range 1–53 mm). All patients were clinically node negative. Thirty-two patients were sentinel lymph node positive, of whom 25 underwent axillary lymph node dissection. Larger tumor size was associated with positive nodes (p < 0.001): the mean tumor size was 14.30 mm in node negative patients and 27.31 mm in node positive patients. Tumor to nipple distance was shorter in node positive patients (51.0 mm) vs. node negative patients (73.3 mm) (p = 0.005). The presence of LVI was associated with nodal positivity (p < 0.001). Tumor quadrant was not associated with nodal metastasis. Ultrasound yielded the largest number of suspicious findings (21/49), with sensitivity of 0.25 and specificity of 0.40. On univariate analysis, age younger than 60 at diagnosis was also associated with nodal positivity (p < 0.002). Comparative analyses with other subtypes may identify biologic determinants. MDPI 2023-09-08 /pmc/articles/PMC10529347/ /pubmed/37754314 http://dx.doi.org/10.3390/diseases11030118 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chintapally, Neha
Englander, Katherine
Gallagher, Julia
Elleson, Kelly
Sun, Weihong
Whiting, Junmin
Laronga, Christine
Lee, Marie Catherine
Tumor Characteristics Associated with Axillary Nodal Positivity in Triple Negative Breast Cancer
title Tumor Characteristics Associated with Axillary Nodal Positivity in Triple Negative Breast Cancer
title_full Tumor Characteristics Associated with Axillary Nodal Positivity in Triple Negative Breast Cancer
title_fullStr Tumor Characteristics Associated with Axillary Nodal Positivity in Triple Negative Breast Cancer
title_full_unstemmed Tumor Characteristics Associated with Axillary Nodal Positivity in Triple Negative Breast Cancer
title_short Tumor Characteristics Associated with Axillary Nodal Positivity in Triple Negative Breast Cancer
title_sort tumor characteristics associated with axillary nodal positivity in triple negative breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529347/
https://www.ncbi.nlm.nih.gov/pubmed/37754314
http://dx.doi.org/10.3390/diseases11030118
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