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Effect of Carcinomas on Autosomal Trait Screening: A Review Article

This review highlights the effect of carcinomas on the results of the examination of autosomal genetic traits for identification and paternity tests when carcinoid tissue is the only source and no other samples are available. In DNA typing or genetic fingerprinting, variable elements are isolated an...

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Autores principales: Alhatim, Husein, Abdullah, Muhammad Nazrul Hakim, Abu Bakar, Suhaili, Amer, Sayed Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529457/
https://www.ncbi.nlm.nih.gov/pubmed/37754244
http://dx.doi.org/10.3390/cimb45090460
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author Alhatim, Husein
Abdullah, Muhammad Nazrul Hakim
Abu Bakar, Suhaili
Amer, Sayed Amin
author_facet Alhatim, Husein
Abdullah, Muhammad Nazrul Hakim
Abu Bakar, Suhaili
Amer, Sayed Amin
author_sort Alhatim, Husein
collection PubMed
description This review highlights the effect of carcinomas on the results of the examination of autosomal genetic traits for identification and paternity tests when carcinoid tissue is the only source and no other samples are available. In DNA typing or genetic fingerprinting, variable elements are isolated and identified within the base pair sequences that form the DNA. The person’s probable identity can be determined by analysing nucleotide sequences in particular regions of DNA unique to everyone. Genetics plays an increasingly important role in the risk stratification and management of carcinoma patients. The available information from previous studies has indicated that in some incidents, including mass disasters and crimes such as terrorist incidents, biological evidence may not be available at the scene of the accident, except for some unknown human remains found in the form of undefined human tissues. If these tissues have cancerous tumours, it may affect the examination of the genetic traits derived from these samples, thereby resulting in a failure to identify the person. Pathology units, more often, verify the identity of the patients who were diagnosed with cancer in reference to their deceased tumorous relatives. Genetic fingerprinting (GF) is also used in paternity testing when the alleged parent disappeared or died and earlier was diagnosed and treated for cancer.
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spelling pubmed-105294572023-09-28 Effect of Carcinomas on Autosomal Trait Screening: A Review Article Alhatim, Husein Abdullah, Muhammad Nazrul Hakim Abu Bakar, Suhaili Amer, Sayed Amin Curr Issues Mol Biol Review This review highlights the effect of carcinomas on the results of the examination of autosomal genetic traits for identification and paternity tests when carcinoid tissue is the only source and no other samples are available. In DNA typing or genetic fingerprinting, variable elements are isolated and identified within the base pair sequences that form the DNA. The person’s probable identity can be determined by analysing nucleotide sequences in particular regions of DNA unique to everyone. Genetics plays an increasingly important role in the risk stratification and management of carcinoma patients. The available information from previous studies has indicated that in some incidents, including mass disasters and crimes such as terrorist incidents, biological evidence may not be available at the scene of the accident, except for some unknown human remains found in the form of undefined human tissues. If these tissues have cancerous tumours, it may affect the examination of the genetic traits derived from these samples, thereby resulting in a failure to identify the person. Pathology units, more often, verify the identity of the patients who were diagnosed with cancer in reference to their deceased tumorous relatives. Genetic fingerprinting (GF) is also used in paternity testing when the alleged parent disappeared or died and earlier was diagnosed and treated for cancer. MDPI 2023-09-04 /pmc/articles/PMC10529457/ /pubmed/37754244 http://dx.doi.org/10.3390/cimb45090460 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alhatim, Husein
Abdullah, Muhammad Nazrul Hakim
Abu Bakar, Suhaili
Amer, Sayed Amin
Effect of Carcinomas on Autosomal Trait Screening: A Review Article
title Effect of Carcinomas on Autosomal Trait Screening: A Review Article
title_full Effect of Carcinomas on Autosomal Trait Screening: A Review Article
title_fullStr Effect of Carcinomas on Autosomal Trait Screening: A Review Article
title_full_unstemmed Effect of Carcinomas on Autosomal Trait Screening: A Review Article
title_short Effect of Carcinomas on Autosomal Trait Screening: A Review Article
title_sort effect of carcinomas on autosomal trait screening: a review article
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529457/
https://www.ncbi.nlm.nih.gov/pubmed/37754244
http://dx.doi.org/10.3390/cimb45090460
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