Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis

Cutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expressio...

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Autores principales: Ariasi, Cesare, Romanò, Carola, Ghini, Iacopo, Licata, Gaetano, Rubelli, Luca, Artelli, Grazia Linda, Calzavara-Pinton, Piergiacomo, Arisi, Mariachiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529716/
https://www.ncbi.nlm.nih.gov/pubmed/37754276
http://dx.doi.org/10.3390/dermatopathology10030034
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author Ariasi, Cesare
Romanò, Carola
Ghini, Iacopo
Licata, Gaetano
Rubelli, Luca
Artelli, Grazia Linda
Calzavara-Pinton, Piergiacomo
Arisi, Mariachiara
author_facet Ariasi, Cesare
Romanò, Carola
Ghini, Iacopo
Licata, Gaetano
Rubelli, Luca
Artelli, Grazia Linda
Calzavara-Pinton, Piergiacomo
Arisi, Mariachiara
author_sort Ariasi, Cesare
collection PubMed
description Cutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expression of smooth muscle and epithelial markers. Fluorescence in situ hybridization (FISH) targeting the EWSR1 gene rearrangement is an important diagnostic tool for CSM. In our case report, we found the focal positivity for CD34, which has never been previously observed; this was mostly confined to a central area of the neoplasm.
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spelling pubmed-105297162023-09-28 Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis Ariasi, Cesare Romanò, Carola Ghini, Iacopo Licata, Gaetano Rubelli, Luca Artelli, Grazia Linda Calzavara-Pinton, Piergiacomo Arisi, Mariachiara Dermatopathology (Basel) Case Report Cutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expression of smooth muscle and epithelial markers. Fluorescence in situ hybridization (FISH) targeting the EWSR1 gene rearrangement is an important diagnostic tool for CSM. In our case report, we found the focal positivity for CD34, which has never been previously observed; this was mostly confined to a central area of the neoplasm. MDPI 2023-08-30 /pmc/articles/PMC10529716/ /pubmed/37754276 http://dx.doi.org/10.3390/dermatopathology10030034 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Ariasi, Cesare
Romanò, Carola
Ghini, Iacopo
Licata, Gaetano
Rubelli, Luca
Artelli, Grazia Linda
Calzavara-Pinton, Piergiacomo
Arisi, Mariachiara
Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis
title Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis
title_full Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis
title_fullStr Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis
title_full_unstemmed Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis
title_short Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis
title_sort cutaneous syncytial myoepithelioma with positive cd34 immunohistochemical staining: an unusual tumor and a challenging diagnosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529716/
https://www.ncbi.nlm.nih.gov/pubmed/37754276
http://dx.doi.org/10.3390/dermatopathology10030034
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