Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart

Elderly patients (age > 75) sustain larger infarcts with greater mortality from ST elevation myocardial infarcts (STEMI) despite successful reperfusion treatment. Elderly age remains an independent risk despite correction for clinical and angiographic variables. The elderly represent a high-risk...

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Autores principales: Bates, Lauryn, Krause-Hauch, Meredith, Wang, Hao, Fatmi, Mohammad Kasim, Li, Zehui, Chen, Qun, Ren, Di, Li, Ji, Lesnefsky, Edward J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529738/
https://www.ncbi.nlm.nih.gov/pubmed/37196121
http://dx.doi.org/10.14336/AD.2023.0205
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author Bates, Lauryn
Krause-Hauch, Meredith
Wang, Hao
Fatmi, Mohammad Kasim
Li, Zehui
Chen, Qun
Ren, Di
Li, Ji
Lesnefsky, Edward J
author_facet Bates, Lauryn
Krause-Hauch, Meredith
Wang, Hao
Fatmi, Mohammad Kasim
Li, Zehui
Chen, Qun
Ren, Di
Li, Ji
Lesnefsky, Edward J
author_sort Bates, Lauryn
collection PubMed
description Elderly patients (age > 75) sustain larger infarcts with greater mortality from ST elevation myocardial infarcts (STEMI) despite successful reperfusion treatment. Elderly age remains an independent risk despite correction for clinical and angiographic variables. The elderly represent a high-risk population and may benefit from treatment in addition to reperfusion alone. We hypothesized that modulation of cardiac signaling and metabolism with acute, high dose metformin given at reperfusion would exhibit additional cardioprotection. Using a translational aging murine model (22-24-month C57BL/6J mice) of in vivo STEMI (45 min artery occlusion with reperfusion for 24 hours); treatment acutely at reperfusion by high dose metformin decreased infarct size and enhanced contractile recovery, demonstrating cardioprotection in the high-risk aging heart.
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spelling pubmed-105297382023-10-01 Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart Bates, Lauryn Krause-Hauch, Meredith Wang, Hao Fatmi, Mohammad Kasim Li, Zehui Chen, Qun Ren, Di Li, Ji Lesnefsky, Edward J Aging Dis Short Communication Elderly patients (age > 75) sustain larger infarcts with greater mortality from ST elevation myocardial infarcts (STEMI) despite successful reperfusion treatment. Elderly age remains an independent risk despite correction for clinical and angiographic variables. The elderly represent a high-risk population and may benefit from treatment in addition to reperfusion alone. We hypothesized that modulation of cardiac signaling and metabolism with acute, high dose metformin given at reperfusion would exhibit additional cardioprotection. Using a translational aging murine model (22-24-month C57BL/6J mice) of in vivo STEMI (45 min artery occlusion with reperfusion for 24 hours); treatment acutely at reperfusion by high dose metformin decreased infarct size and enhanced contractile recovery, demonstrating cardioprotection in the high-risk aging heart. JKL International LLC 2023-10-01 /pmc/articles/PMC10529738/ /pubmed/37196121 http://dx.doi.org/10.14336/AD.2023.0205 Text en copyright: © 2023 Bates et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Short Communication
Bates, Lauryn
Krause-Hauch, Meredith
Wang, Hao
Fatmi, Mohammad Kasim
Li, Zehui
Chen, Qun
Ren, Di
Li, Ji
Lesnefsky, Edward J
Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart
title Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart
title_full Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart
title_fullStr Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart
title_full_unstemmed Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart
title_short Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart
title_sort acute, high dose metformin therapy at reperfusion decreases infarct size in the high-risk aging heart
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529738/
https://www.ncbi.nlm.nih.gov/pubmed/37196121
http://dx.doi.org/10.14336/AD.2023.0205
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