Matrix Stiffness Activating YAP/TEAD1-Cyclin B1 in Nucleus Pulposus Cells Promotes Intervertebral Disc Degeneration

Intervertebral disc degeneration is a leading cause of disability in the elderly population. Rigid extracellular matrix is a critical pathological feature of disc degeneration, leading to aberrant nucleus pulposus cells (NPCs) proliferation. However, the underlying mechanism is unclear. Here, we hyp...

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Detalles Bibliográficos
Autores principales: Zhou, Zijie, Suo, Yinxuan, Bai, Jinyu, Lin, Fanguo, Gao, Xiang, Shan, Huajian, Ni, Yichao, Zhou, Xiaozhong, Sheng, Lei, Dai, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529754/
http://dx.doi.org/10.14336/AD.2023.00205-1

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