Cargando…
Psychosis Caused by a Somatic Condition: How to Make the Diagnosis? A Systematic Literature Review
Background: First episode of psychosis (FEP) is a clinical condition that usually occurs during adolescence or early adulthood and is often a sign of a future psychiatric disease. However, these symptoms are not specific, and psychosis can be caused by a physical disease in at least 5% of cases. Tim...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529854/ https://www.ncbi.nlm.nih.gov/pubmed/37761400 http://dx.doi.org/10.3390/children10091439 |
_version_ | 1785111440747659264 |
---|---|
author | Dissaux, Nolwenn Neyme, Pierre Kim-Dufor, Deok-Hee Lavenne-Collot, Nathalie Marsh, Jonathan J. Berrouiguet, Sofian Walter, Michel Lemey, Christophe |
author_facet | Dissaux, Nolwenn Neyme, Pierre Kim-Dufor, Deok-Hee Lavenne-Collot, Nathalie Marsh, Jonathan J. Berrouiguet, Sofian Walter, Michel Lemey, Christophe |
author_sort | Dissaux, Nolwenn |
collection | PubMed |
description | Background: First episode of psychosis (FEP) is a clinical condition that usually occurs during adolescence or early adulthood and is often a sign of a future psychiatric disease. However, these symptoms are not specific, and psychosis can be caused by a physical disease in at least 5% of cases. Timely detection of these diseases, the first signs of which may appear in childhood, is of particular importance, as a curable treatment exists in most cases. However, there is no consensus in academic societies to offer recommendations for a comprehensive medical assessment to eliminate somatic causes. Methods: We conducted a systematic literature search using a two-fold research strategy to: (1) identify physical diseases that can be differentially diagnosed for psychosis; and (2) determine the paraclinical exams allowing us to exclude these pathologies. Results: We identified 85 articles describing the autoimmune, metabolic, neurologic, infectious, and genetic differential diagnoses of psychosis. Clinical presentations are described, and a complete list of laboratory and imaging features required to identify and confirm these diseases is provided. Conclusion: This systematic review shows that most differential diagnoses of psychosis should be considered in the case of a FEP and could be identified by providing a systematic checkup with a laboratory test that includes ammonemia, antinuclear and anti-NMDA antibodies, and HIV testing; brain magnetic resonance imaging and lumbar puncture should be considered according to the clinical presentation. Genetic research could be of interest to patients presenting with physical or developmental symptoms associated with psychiatric manifestations. |
format | Online Article Text |
id | pubmed-10529854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105298542023-09-28 Psychosis Caused by a Somatic Condition: How to Make the Diagnosis? A Systematic Literature Review Dissaux, Nolwenn Neyme, Pierre Kim-Dufor, Deok-Hee Lavenne-Collot, Nathalie Marsh, Jonathan J. Berrouiguet, Sofian Walter, Michel Lemey, Christophe Children (Basel) Review Background: First episode of psychosis (FEP) is a clinical condition that usually occurs during adolescence or early adulthood and is often a sign of a future psychiatric disease. However, these symptoms are not specific, and psychosis can be caused by a physical disease in at least 5% of cases. Timely detection of these diseases, the first signs of which may appear in childhood, is of particular importance, as a curable treatment exists in most cases. However, there is no consensus in academic societies to offer recommendations for a comprehensive medical assessment to eliminate somatic causes. Methods: We conducted a systematic literature search using a two-fold research strategy to: (1) identify physical diseases that can be differentially diagnosed for psychosis; and (2) determine the paraclinical exams allowing us to exclude these pathologies. Results: We identified 85 articles describing the autoimmune, metabolic, neurologic, infectious, and genetic differential diagnoses of psychosis. Clinical presentations are described, and a complete list of laboratory and imaging features required to identify and confirm these diseases is provided. Conclusion: This systematic review shows that most differential diagnoses of psychosis should be considered in the case of a FEP and could be identified by providing a systematic checkup with a laboratory test that includes ammonemia, antinuclear and anti-NMDA antibodies, and HIV testing; brain magnetic resonance imaging and lumbar puncture should be considered according to the clinical presentation. Genetic research could be of interest to patients presenting with physical or developmental symptoms associated with psychiatric manifestations. MDPI 2023-08-23 /pmc/articles/PMC10529854/ /pubmed/37761400 http://dx.doi.org/10.3390/children10091439 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dissaux, Nolwenn Neyme, Pierre Kim-Dufor, Deok-Hee Lavenne-Collot, Nathalie Marsh, Jonathan J. Berrouiguet, Sofian Walter, Michel Lemey, Christophe Psychosis Caused by a Somatic Condition: How to Make the Diagnosis? A Systematic Literature Review |
title | Psychosis Caused by a Somatic Condition: How to Make the Diagnosis? A Systematic Literature Review |
title_full | Psychosis Caused by a Somatic Condition: How to Make the Diagnosis? A Systematic Literature Review |
title_fullStr | Psychosis Caused by a Somatic Condition: How to Make the Diagnosis? A Systematic Literature Review |
title_full_unstemmed | Psychosis Caused by a Somatic Condition: How to Make the Diagnosis? A Systematic Literature Review |
title_short | Psychosis Caused by a Somatic Condition: How to Make the Diagnosis? A Systematic Literature Review |
title_sort | psychosis caused by a somatic condition: how to make the diagnosis? a systematic literature review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529854/ https://www.ncbi.nlm.nih.gov/pubmed/37761400 http://dx.doi.org/10.3390/children10091439 |
work_keys_str_mv | AT dissauxnolwenn psychosiscausedbyasomaticconditionhowtomakethediagnosisasystematicliteraturereview AT neymepierre psychosiscausedbyasomaticconditionhowtomakethediagnosisasystematicliteraturereview AT kimdufordeokhee psychosiscausedbyasomaticconditionhowtomakethediagnosisasystematicliteraturereview AT lavennecollotnathalie psychosiscausedbyasomaticconditionhowtomakethediagnosisasystematicliteraturereview AT marshjonathanj psychosiscausedbyasomaticconditionhowtomakethediagnosisasystematicliteraturereview AT berrouiguetsofian psychosiscausedbyasomaticconditionhowtomakethediagnosisasystematicliteraturereview AT waltermichel psychosiscausedbyasomaticconditionhowtomakethediagnosisasystematicliteraturereview AT lemeychristophe psychosiscausedbyasomaticconditionhowtomakethediagnosisasystematicliteraturereview |