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Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial
In the context of liver surgery, predicting postoperative liver dysfunction is essential. This study explored the potential of preoperative liver function assessment by MRI for predicting postoperative liver dysfunction and compared these results with the established indocyanine green (ICG) clearanc...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529888/ https://www.ncbi.nlm.nih.gov/pubmed/37761381 http://dx.doi.org/10.3390/diagnostics13183014 |
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author | Verloh, Niklas Rio Bartulos, Carolina Utpatel, Kirsten Brennfleck, Frank Goetz, Andrea Schicho, Andreas Fellner, Claudia Nickel, Dominik Zeman, Florian Steinmann, Johannes F. Uller, Wibke Stroszczynski, Christian Schlitt, Hans-Jürgen Wiggermann, Phillip Haimerl, Michael |
author_facet | Verloh, Niklas Rio Bartulos, Carolina Utpatel, Kirsten Brennfleck, Frank Goetz, Andrea Schicho, Andreas Fellner, Claudia Nickel, Dominik Zeman, Florian Steinmann, Johannes F. Uller, Wibke Stroszczynski, Christian Schlitt, Hans-Jürgen Wiggermann, Phillip Haimerl, Michael |
author_sort | Verloh, Niklas |
collection | PubMed |
description | In the context of liver surgery, predicting postoperative liver dysfunction is essential. This study explored the potential of preoperative liver function assessment by MRI for predicting postoperative liver dysfunction and compared these results with the established indocyanine green (ICG) clearance test. This prospective study included patients undergoing liver resection with preoperative MRI planning. Liver function was quantified using T1 relaxometry and correlated with established liver function scores. The analysis revealed an improved model for predicting postoperative liver dysfunction, exhibiting an accuracy (ACC) of 0.79, surpassing the 0.70 of the preoperative ICG test, alongside a higher area under the curve (0.75). Notably, the proposed model also successfully predicted all cases of liver failure and showed potential in predicting liver synthesis dysfunction (ACC 0.78). This model showed promise in patient survival rates with a Hazard ratio of 0.87, underscoring its potential as a valuable tool for preoperative evaluation. The findings imply that MRI-based assessment of liver function can provide significant benefits in the early identification and management of patients at risk for postoperative liver dysfunction. |
format | Online Article Text |
id | pubmed-10529888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105298882023-09-28 Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial Verloh, Niklas Rio Bartulos, Carolina Utpatel, Kirsten Brennfleck, Frank Goetz, Andrea Schicho, Andreas Fellner, Claudia Nickel, Dominik Zeman, Florian Steinmann, Johannes F. Uller, Wibke Stroszczynski, Christian Schlitt, Hans-Jürgen Wiggermann, Phillip Haimerl, Michael Diagnostics (Basel) Article In the context of liver surgery, predicting postoperative liver dysfunction is essential. This study explored the potential of preoperative liver function assessment by MRI for predicting postoperative liver dysfunction and compared these results with the established indocyanine green (ICG) clearance test. This prospective study included patients undergoing liver resection with preoperative MRI planning. Liver function was quantified using T1 relaxometry and correlated with established liver function scores. The analysis revealed an improved model for predicting postoperative liver dysfunction, exhibiting an accuracy (ACC) of 0.79, surpassing the 0.70 of the preoperative ICG test, alongside a higher area under the curve (0.75). Notably, the proposed model also successfully predicted all cases of liver failure and showed potential in predicting liver synthesis dysfunction (ACC 0.78). This model showed promise in patient survival rates with a Hazard ratio of 0.87, underscoring its potential as a valuable tool for preoperative evaluation. The findings imply that MRI-based assessment of liver function can provide significant benefits in the early identification and management of patients at risk for postoperative liver dysfunction. MDPI 2023-09-21 /pmc/articles/PMC10529888/ /pubmed/37761381 http://dx.doi.org/10.3390/diagnostics13183014 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Verloh, Niklas Rio Bartulos, Carolina Utpatel, Kirsten Brennfleck, Frank Goetz, Andrea Schicho, Andreas Fellner, Claudia Nickel, Dominik Zeman, Florian Steinmann, Johannes F. Uller, Wibke Stroszczynski, Christian Schlitt, Hans-Jürgen Wiggermann, Phillip Haimerl, Michael Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial |
title | Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial |
title_full | Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial |
title_fullStr | Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial |
title_full_unstemmed | Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial |
title_short | Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial |
title_sort | volume-assisted estimation of remnant liver function based on gd-eob-dtpa enhanced mr relaxometry: a prospective observational trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529888/ https://www.ncbi.nlm.nih.gov/pubmed/37761381 http://dx.doi.org/10.3390/diagnostics13183014 |
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