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The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery

The delivery of active molecules via the skin seems to be an efficient technology, given the various disadvantages of oral drug administration. Skin, which is the largest human organ of the body, has the important role of acting as a barrier for pathogens and other molecules including drugs; in fact...

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Autores principales: Siafaka, Panoraia I., Özcan Bülbül, Ece, Okur, Mehmet Evren, Karantas, Ioannis D., Üstündağ Okur, Neslihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529964/
https://www.ncbi.nlm.nih.gov/pubmed/37754434
http://dx.doi.org/10.3390/gels9090753
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author Siafaka, Panoraia I.
Özcan Bülbül, Ece
Okur, Mehmet Evren
Karantas, Ioannis D.
Üstündağ Okur, Neslihan
author_facet Siafaka, Panoraia I.
Özcan Bülbül, Ece
Okur, Mehmet Evren
Karantas, Ioannis D.
Üstündağ Okur, Neslihan
author_sort Siafaka, Panoraia I.
collection PubMed
description The delivery of active molecules via the skin seems to be an efficient technology, given the various disadvantages of oral drug administration. Skin, which is the largest human organ of the body, has the important role of acting as a barrier for pathogens and other molecules including drugs; in fact, it serves as a primary defense system blocking any particle from entering the body. Therefore, to overcome the skin barriers and poor skin permeability, researchers implement novel carriers which can effectively carry out transdermal delivery of the molecules. Another significant issue which medical society tries to solve is the effective dermal delivery of molecules especially for topical wound delivery. The application of nanogels is only one of the available approaches offering promising results for both dermal and transdermal administration routes. Nanogels are polymer-based networks in nanoscale dimensions which have been explored as potent carriers of poorly soluble drugs, genes and vaccines. The nanogels present unique physicochemical properties, i.e., high surface area, biocompatibility, etc., and, importantly, can improve solubility. In this review, authors aimed to summarize the available applications of nanogels as possible vehicles for dermal and transdermal delivery of active pharmaceutical ingredients and discuss their future in the pharmaceutical manufacturing field.
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spelling pubmed-105299642023-09-28 The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery Siafaka, Panoraia I. Özcan Bülbül, Ece Okur, Mehmet Evren Karantas, Ioannis D. Üstündağ Okur, Neslihan Gels Review The delivery of active molecules via the skin seems to be an efficient technology, given the various disadvantages of oral drug administration. Skin, which is the largest human organ of the body, has the important role of acting as a barrier for pathogens and other molecules including drugs; in fact, it serves as a primary defense system blocking any particle from entering the body. Therefore, to overcome the skin barriers and poor skin permeability, researchers implement novel carriers which can effectively carry out transdermal delivery of the molecules. Another significant issue which medical society tries to solve is the effective dermal delivery of molecules especially for topical wound delivery. The application of nanogels is only one of the available approaches offering promising results for both dermal and transdermal administration routes. Nanogels are polymer-based networks in nanoscale dimensions which have been explored as potent carriers of poorly soluble drugs, genes and vaccines. The nanogels present unique physicochemical properties, i.e., high surface area, biocompatibility, etc., and, importantly, can improve solubility. In this review, authors aimed to summarize the available applications of nanogels as possible vehicles for dermal and transdermal delivery of active pharmaceutical ingredients and discuss their future in the pharmaceutical manufacturing field. MDPI 2023-09-15 /pmc/articles/PMC10529964/ /pubmed/37754434 http://dx.doi.org/10.3390/gels9090753 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Siafaka, Panoraia I.
Özcan Bülbül, Ece
Okur, Mehmet Evren
Karantas, Ioannis D.
Üstündağ Okur, Neslihan
The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery
title The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery
title_full The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery
title_fullStr The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery
title_full_unstemmed The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery
title_short The Application of Nanogels as Efficient Drug Delivery Platforms for Dermal/Transdermal Delivery
title_sort application of nanogels as efficient drug delivery platforms for dermal/transdermal delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529964/
https://www.ncbi.nlm.nih.gov/pubmed/37754434
http://dx.doi.org/10.3390/gels9090753
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