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Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?

Spexin (SPX) is a peptide that plays an important role in the regulation of food intake and body weight (BW) by the effect on carbohydrate-lipid metabolism. However, the role of SPX in fetal life, in children, and in adolescent metabolism is limited. Therefore, we decided to check whether obesity af...

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Autores principales: Wojciechowska, Malgorzata, Kolodziejski, Pawel A., Pruszynska-Oszmalek, Ewa, Leciejewska, Natalia, Krauss, Hanna, Checinska-Maciejewska, Zuzanna, Sassek, Maciej, Rekas-Dudziak, Anna, Bernatek, Malgorzata, Skrzypski, Marek, Wilczak, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530094/
https://www.ncbi.nlm.nih.gov/pubmed/37761477
http://dx.doi.org/10.3390/children10091517
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author Wojciechowska, Malgorzata
Kolodziejski, Pawel A.
Pruszynska-Oszmalek, Ewa
Leciejewska, Natalia
Krauss, Hanna
Checinska-Maciejewska, Zuzanna
Sassek, Maciej
Rekas-Dudziak, Anna
Bernatek, Malgorzata
Skrzypski, Marek
Wilczak, Maciej
author_facet Wojciechowska, Malgorzata
Kolodziejski, Pawel A.
Pruszynska-Oszmalek, Ewa
Leciejewska, Natalia
Krauss, Hanna
Checinska-Maciejewska, Zuzanna
Sassek, Maciej
Rekas-Dudziak, Anna
Bernatek, Malgorzata
Skrzypski, Marek
Wilczak, Maciej
author_sort Wojciechowska, Malgorzata
collection PubMed
description Spexin (SPX) is a peptide that plays an important role in the regulation of food intake and body weight (BW) by the effect on carbohydrate-lipid metabolism. However, the role of SPX in fetal life, in children, and in adolescent metabolism is limited. Therefore, we decided to check whether obesity affects the concentration of SPX in the mother’s peripheral blood (MB) and umbilical cord blood (UCB). Using MB and UCB sera on the day of delivery obtained from 48 women (24 non-obese and 24 obese) and commercially available Elisa kits and colorimetric assays, we determined changes in SPX and the relationship between SPX concentration and other metabolic and anthropometric markers (body weight and BMI) on the day of delivery and in children at the age of 36 months. We found lower concentrations of SPX in MB (p < 0.05) and UCB (p < 0.01) derived from obese women (BMI > 30) and a moderate linear correlation (r = 0.4429; p < 0.01) between SPX concentrations in MB and UCB. We also noted that the concentration of SPX is not correlated with the child’s body weight on the day of birth (r = −0.0128). However, there is a relationship between SPX at birth and body weight at 3 years of age (r = −0.3219; p < 0.05). Based on the obtained results, it can be assumed that spexin is one of the factors modulating the child’s metabolism already in the fetal period and can be considered a potential marker of future predisposition to obesity. However, confirmation of this thesis requires additional research.
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spelling pubmed-105300942023-09-28 Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity? Wojciechowska, Malgorzata Kolodziejski, Pawel A. Pruszynska-Oszmalek, Ewa Leciejewska, Natalia Krauss, Hanna Checinska-Maciejewska, Zuzanna Sassek, Maciej Rekas-Dudziak, Anna Bernatek, Malgorzata Skrzypski, Marek Wilczak, Maciej Children (Basel) Article Spexin (SPX) is a peptide that plays an important role in the regulation of food intake and body weight (BW) by the effect on carbohydrate-lipid metabolism. However, the role of SPX in fetal life, in children, and in adolescent metabolism is limited. Therefore, we decided to check whether obesity affects the concentration of SPX in the mother’s peripheral blood (MB) and umbilical cord blood (UCB). Using MB and UCB sera on the day of delivery obtained from 48 women (24 non-obese and 24 obese) and commercially available Elisa kits and colorimetric assays, we determined changes in SPX and the relationship between SPX concentration and other metabolic and anthropometric markers (body weight and BMI) on the day of delivery and in children at the age of 36 months. We found lower concentrations of SPX in MB (p < 0.05) and UCB (p < 0.01) derived from obese women (BMI > 30) and a moderate linear correlation (r = 0.4429; p < 0.01) between SPX concentrations in MB and UCB. We also noted that the concentration of SPX is not correlated with the child’s body weight on the day of birth (r = −0.0128). However, there is a relationship between SPX at birth and body weight at 3 years of age (r = −0.3219; p < 0.05). Based on the obtained results, it can be assumed that spexin is one of the factors modulating the child’s metabolism already in the fetal period and can be considered a potential marker of future predisposition to obesity. However, confirmation of this thesis requires additional research. MDPI 2023-09-06 /pmc/articles/PMC10530094/ /pubmed/37761477 http://dx.doi.org/10.3390/children10091517 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wojciechowska, Malgorzata
Kolodziejski, Pawel A.
Pruszynska-Oszmalek, Ewa
Leciejewska, Natalia
Krauss, Hanna
Checinska-Maciejewska, Zuzanna
Sassek, Maciej
Rekas-Dudziak, Anna
Bernatek, Malgorzata
Skrzypski, Marek
Wilczak, Maciej
Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?
title Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?
title_full Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?
title_fullStr Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?
title_full_unstemmed Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?
title_short Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?
title_sort cord blood spexin level in mothers with obesity—forecast of future obesity?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530094/
https://www.ncbi.nlm.nih.gov/pubmed/37761477
http://dx.doi.org/10.3390/children10091517
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