Genotype-specific precision tumor therapy using mitochondrial DNA mutation-induced drug release system

Precise killing of tumor cells without affecting surrounding normal cells is a challenge. Mitochondrial DNA (mtDNA) mutations, a common genetic variant in cancer, can directly affect metabolic homeostasis, serving as an ideal regulatory switch for precise tumor therapy. Here, we designed a mutation-...

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Detalles Bibliográficos
Autores principales: Li, Yanan, Xu, Ru, Wu, Yonghua, Guo, Jialing, Quan, Fenglei, Pei, Yiran, Huang, Di, Zhao, Xiu, Gao, Hua, Liu, Junjie, Zhang, Zhenzhong, Shi, Jinjin, Zhang, Kaixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530102/
https://www.ncbi.nlm.nih.gov/pubmed/37756407
http://dx.doi.org/10.1126/sciadv.adi1965

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