A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies

Statins competitively inhibit the activity of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), which is a key enzyme in cholesterol synthesis. These are effective drugs for the management of cardiovascular disease and are generally well tolerated but several side effects have been reported....

Descripción completa

Detalles Bibliográficos
Autores principales: Chérif, Mohammad Yassine, Raftakis, Ioannis, Weynand, Marjolaine, Dragan, Elena, Nagant, Carole, Lecomte, Sophie, Badot, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530299/
https://www.ncbi.nlm.nih.gov/pubmed/37771688
http://dx.doi.org/10.1093/omcr/omad097
_version_ 1785111498032414720
author Chérif, Mohammad Yassine
Raftakis, Ioannis
Weynand, Marjolaine
Dragan, Elena
Nagant, Carole
Lecomte, Sophie
Badot, Valérie
author_facet Chérif, Mohammad Yassine
Raftakis, Ioannis
Weynand, Marjolaine
Dragan, Elena
Nagant, Carole
Lecomte, Sophie
Badot, Valérie
author_sort Chérif, Mohammad Yassine
collection PubMed
description Statins competitively inhibit the activity of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), which is a key enzyme in cholesterol synthesis. These are effective drugs for the management of cardiovascular disease and are generally well tolerated but several side effects have been reported. Muscular adverse symptoms are various and, rarely, statin exposure may lead to authentic immune-mediated necrotizing myopathy (IMNM), namely anti-HMGCR myopathy. However, cases of IMNM associated with cancer have been described. We discuss herein a case of IMNM in a patient with breast cancer previously exposed to statins and with the presence of anti-Th/To antibodies without clinical correlation.
format Online
Article
Text
id pubmed-10530299
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-105302992023-09-28 A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies Chérif, Mohammad Yassine Raftakis, Ioannis Weynand, Marjolaine Dragan, Elena Nagant, Carole Lecomte, Sophie Badot, Valérie Oxf Med Case Reports Case Report Statins competitively inhibit the activity of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), which is a key enzyme in cholesterol synthesis. These are effective drugs for the management of cardiovascular disease and are generally well tolerated but several side effects have been reported. Muscular adverse symptoms are various and, rarely, statin exposure may lead to authentic immune-mediated necrotizing myopathy (IMNM), namely anti-HMGCR myopathy. However, cases of IMNM associated with cancer have been described. We discuss herein a case of IMNM in a patient with breast cancer previously exposed to statins and with the presence of anti-Th/To antibodies without clinical correlation. Oxford University Press 2023-09-25 /pmc/articles/PMC10530299/ /pubmed/37771688 http://dx.doi.org/10.1093/omcr/omad097 Text en © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Chérif, Mohammad Yassine
Raftakis, Ioannis
Weynand, Marjolaine
Dragan, Elena
Nagant, Carole
Lecomte, Sophie
Badot, Valérie
A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies
title A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies
title_full A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies
title_fullStr A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies
title_full_unstemmed A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies
title_short A case of anti-HMGCR myopathy in a patient with breast cancer and anti-Th/To antibodies
title_sort case of anti-hmgcr myopathy in a patient with breast cancer and anti-th/to antibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530299/
https://www.ncbi.nlm.nih.gov/pubmed/37771688
http://dx.doi.org/10.1093/omcr/omad097
work_keys_str_mv AT cherifmohammadyassine acaseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT raftakisioannis acaseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT weynandmarjolaine acaseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT draganelena acaseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT nagantcarole acaseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT lecomtesophie acaseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT badotvalerie acaseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT cherifmohammadyassine caseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT raftakisioannis caseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT weynandmarjolaine caseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT draganelena caseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT nagantcarole caseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT lecomtesophie caseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies
AT badotvalerie caseofantihmgcrmyopathyinapatientwithbreastcancerandantithtoantibodies

Ejemplares similares