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Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report
We report a patient with a novel presentation of anti-neutrophil cytoplasmic antibody positive (ANCA+) vasculitis of the brain and oral mucosa. ANCA+ vasculitis of the brain is usually associated with pachymeningitis and hypophysitis, and there are no cases reported with simultaneous brain and oral...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530312/ https://www.ncbi.nlm.nih.gov/pubmed/37771681 http://dx.doi.org/10.1093/omcr/omad100 |
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author | Bontempo, D Frydrych, A M Kujan, O Gebauer, D Fallon, M Panegyres, P K |
author_facet | Bontempo, D Frydrych, A M Kujan, O Gebauer, D Fallon, M Panegyres, P K |
author_sort | Bontempo, D |
collection | PubMed |
description | We report a patient with a novel presentation of anti-neutrophil cytoplasmic antibody positive (ANCA+) vasculitis of the brain and oral mucosa. ANCA+ vasculitis of the brain is usually associated with pachymeningitis and hypophysitis, and there are no cases reported with simultaneous brain and oral mucosal involvement. A 35-year-old African Zambian man presented with headache and bleeding swollen gingiva. He was myeloperoxidase (MPO) antibody positive with cytoplasmic staining. His MRI showed stable small callosal, periventricular and subcortical white matter non-enhancing lesions, without change over 15 months—compatible with vasculitis. His gingival biopsy was consistent with vasculitis. His headache and oral lesions responded to oral corticosteroids and intravenous immunoglobulin which have induced clinical remission. Our patient expands the clinical syndrome of ANCA+ MPO+ C-type vasculitis of the central nervous system with headaches complicating cerebral vasculitis and oral mucosal involvement. |
format | Online Article Text |
id | pubmed-10530312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105303122023-09-28 Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report Bontempo, D Frydrych, A M Kujan, O Gebauer, D Fallon, M Panegyres, P K Oxf Med Case Reports Case Report We report a patient with a novel presentation of anti-neutrophil cytoplasmic antibody positive (ANCA+) vasculitis of the brain and oral mucosa. ANCA+ vasculitis of the brain is usually associated with pachymeningitis and hypophysitis, and there are no cases reported with simultaneous brain and oral mucosal involvement. A 35-year-old African Zambian man presented with headache and bleeding swollen gingiva. He was myeloperoxidase (MPO) antibody positive with cytoplasmic staining. His MRI showed stable small callosal, periventricular and subcortical white matter non-enhancing lesions, without change over 15 months—compatible with vasculitis. His gingival biopsy was consistent with vasculitis. His headache and oral lesions responded to oral corticosteroids and intravenous immunoglobulin which have induced clinical remission. Our patient expands the clinical syndrome of ANCA+ MPO+ C-type vasculitis of the central nervous system with headaches complicating cerebral vasculitis and oral mucosal involvement. Oxford University Press 2023-09-25 /pmc/articles/PMC10530312/ /pubmed/37771681 http://dx.doi.org/10.1093/omcr/omad100 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Bontempo, D Frydrych, A M Kujan, O Gebauer, D Fallon, M Panegyres, P K Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report |
title | Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report |
title_full | Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report |
title_fullStr | Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report |
title_full_unstemmed | Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report |
title_short | Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report |
title_sort | anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530312/ https://www.ncbi.nlm.nih.gov/pubmed/37771681 http://dx.doi.org/10.1093/omcr/omad100 |
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