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Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update

Non-coding RNAs (ncRNAs) are indispensable for adjusting gene expression and genetic programming throughout development and for health as well as cardiovascular diseases. Cardiac arrhythmia is a frequent cardiovascular disease that has a complex pathology. Recent studies have shown that ncRNAs are a...

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Detalles Bibliográficos
Autores principales: Suga, Naoko, Ikeda, Yuka, Yoshikawa, Sayuri, Taniguchi, Kurumi, Sawamura, Haruka, Matsuda, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530369/
https://www.ncbi.nlm.nih.gov/pubmed/37761875
http://dx.doi.org/10.3390/genes14091736
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author Suga, Naoko
Ikeda, Yuka
Yoshikawa, Sayuri
Taniguchi, Kurumi
Sawamura, Haruka
Matsuda, Satoru
author_facet Suga, Naoko
Ikeda, Yuka
Yoshikawa, Sayuri
Taniguchi, Kurumi
Sawamura, Haruka
Matsuda, Satoru
author_sort Suga, Naoko
collection PubMed
description Non-coding RNAs (ncRNAs) are indispensable for adjusting gene expression and genetic programming throughout development and for health as well as cardiovascular diseases. Cardiac arrhythmia is a frequent cardiovascular disease that has a complex pathology. Recent studies have shown that ncRNAs are also associated with cardiac arrhythmias. Many non-coding RNAs and/or genomes have been reported as genetic background for cardiac arrhythmias. In general, arrhythmias may be affected by several functional and structural changes in the myocardium of the heart. Therefore, ncRNAs might be indispensable regulators of gene expression in cardiomyocytes, which could play a dynamic role in regulating the stability of cardiac conduction and/or in the remodeling process. Although it remains almost unclear how ncRNAs regulate the expression of molecules for controlling cardiac conduction and/or the remodeling process, the gut microbiota and immune system within the intricate networks might be involved in the regulatory mechanisms. This study would discuss them and provide a research basis for ncRNA modulation, which might support the development of emerging innovative therapies against cardiac arrhythmias.
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spelling pubmed-105303692023-09-28 Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update Suga, Naoko Ikeda, Yuka Yoshikawa, Sayuri Taniguchi, Kurumi Sawamura, Haruka Matsuda, Satoru Genes (Basel) Review Non-coding RNAs (ncRNAs) are indispensable for adjusting gene expression and genetic programming throughout development and for health as well as cardiovascular diseases. Cardiac arrhythmia is a frequent cardiovascular disease that has a complex pathology. Recent studies have shown that ncRNAs are also associated with cardiac arrhythmias. Many non-coding RNAs and/or genomes have been reported as genetic background for cardiac arrhythmias. In general, arrhythmias may be affected by several functional and structural changes in the myocardium of the heart. Therefore, ncRNAs might be indispensable regulators of gene expression in cardiomyocytes, which could play a dynamic role in regulating the stability of cardiac conduction and/or in the remodeling process. Although it remains almost unclear how ncRNAs regulate the expression of molecules for controlling cardiac conduction and/or the remodeling process, the gut microbiota and immune system within the intricate networks might be involved in the regulatory mechanisms. This study would discuss them and provide a research basis for ncRNA modulation, which might support the development of emerging innovative therapies against cardiac arrhythmias. MDPI 2023-08-30 /pmc/articles/PMC10530369/ /pubmed/37761875 http://dx.doi.org/10.3390/genes14091736 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Suga, Naoko
Ikeda, Yuka
Yoshikawa, Sayuri
Taniguchi, Kurumi
Sawamura, Haruka
Matsuda, Satoru
Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update
title Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update
title_full Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update
title_fullStr Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update
title_full_unstemmed Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update
title_short Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update
title_sort non-coding rnas and gut microbiota in the pathogenesis of cardiac arrhythmias: the latest update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530369/
https://www.ncbi.nlm.nih.gov/pubmed/37761875
http://dx.doi.org/10.3390/genes14091736
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