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Serum Amino Acid Profiling in Children with Autistic Spectrum Disorder: Insights from a Single-Center Study in Southern Romania

The objective of this study was to analyze the serum amino acid profile in children diagnosed with autistic spectrum disorder (ASD) in southern Romania. The analysis aimed to provide insights into the underlying metabolic dysregulations associated with ASD. ASD is a neurodevelopmental disorder chara...

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Autores principales: Anastasescu, Cătălina Mihaela, Gheorman, Veronica, Popescu, Florica, Stoicănescu, Eugen-Cristi, Gheorman, Victor, Riza, Anca-Lelia, Badea, Oana, Streață, Ioana, Militaru, Felicia, Udriștoiu, Ion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530373/
https://www.ncbi.nlm.nih.gov/pubmed/37761684
http://dx.doi.org/10.3390/healthcare11182487
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author Anastasescu, Cătălina Mihaela
Gheorman, Veronica
Popescu, Florica
Stoicănescu, Eugen-Cristi
Gheorman, Victor
Riza, Anca-Lelia
Badea, Oana
Streață, Ioana
Militaru, Felicia
Udriștoiu, Ion
author_facet Anastasescu, Cătălina Mihaela
Gheorman, Veronica
Popescu, Florica
Stoicănescu, Eugen-Cristi
Gheorman, Victor
Riza, Anca-Lelia
Badea, Oana
Streață, Ioana
Militaru, Felicia
Udriștoiu, Ion
author_sort Anastasescu, Cătălina Mihaela
collection PubMed
description The objective of this study was to analyze the serum amino acid profile in children diagnosed with autistic spectrum disorder (ASD) in southern Romania. The analysis aimed to provide insights into the underlying metabolic dysregulations associated with ASD. ASD is a neurodevelopmental disorder characterized by impaired social interaction, communication deficits, and restricted repetitive behaviors. Although the exact cause of ASD is largely unknown, recent evidence suggests that abnormalities in amino acid metabolism may contribute to its pathogenesis. Therefore, studying the amino acid profile in children with ASD could offer valuable information for understanding the metabolic disturbances associated with this complex disorder. This single-center study examined serum samples from children diagnosed with ASD, utilizing advanced analytical techniques to quantify the levels of different amino acids, amino acid derivatives, and amino acid-like substances. The results showed a lower level of taurine and a higher level of asparagine and leucine in the ASD group versus the control group. In the ASD group, we observed significant differences in tryptophan and alpha-aminobutyric acid levels based on age, with higher tryptophan levels in children older than 7 years when compared to children younger than 7 years; however, no significant correlations were found with the ASD group older than 7 years old. Additionally, younger children with ASD exhibited higher levels of alpha-aminobutyric acid than older children with ASD. The findings from this study contribute to the growing body of knowledge on the metabolic aspects of ASD, highlighting potential biomarkers and therapeutic targets for improving the management and treatment of ASD in children.
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spelling pubmed-105303732023-09-28 Serum Amino Acid Profiling in Children with Autistic Spectrum Disorder: Insights from a Single-Center Study in Southern Romania Anastasescu, Cătălina Mihaela Gheorman, Veronica Popescu, Florica Stoicănescu, Eugen-Cristi Gheorman, Victor Riza, Anca-Lelia Badea, Oana Streață, Ioana Militaru, Felicia Udriștoiu, Ion Healthcare (Basel) Article The objective of this study was to analyze the serum amino acid profile in children diagnosed with autistic spectrum disorder (ASD) in southern Romania. The analysis aimed to provide insights into the underlying metabolic dysregulations associated with ASD. ASD is a neurodevelopmental disorder characterized by impaired social interaction, communication deficits, and restricted repetitive behaviors. Although the exact cause of ASD is largely unknown, recent evidence suggests that abnormalities in amino acid metabolism may contribute to its pathogenesis. Therefore, studying the amino acid profile in children with ASD could offer valuable information for understanding the metabolic disturbances associated with this complex disorder. This single-center study examined serum samples from children diagnosed with ASD, utilizing advanced analytical techniques to quantify the levels of different amino acids, amino acid derivatives, and amino acid-like substances. The results showed a lower level of taurine and a higher level of asparagine and leucine in the ASD group versus the control group. In the ASD group, we observed significant differences in tryptophan and alpha-aminobutyric acid levels based on age, with higher tryptophan levels in children older than 7 years when compared to children younger than 7 years; however, no significant correlations were found with the ASD group older than 7 years old. Additionally, younger children with ASD exhibited higher levels of alpha-aminobutyric acid than older children with ASD. The findings from this study contribute to the growing body of knowledge on the metabolic aspects of ASD, highlighting potential biomarkers and therapeutic targets for improving the management and treatment of ASD in children. MDPI 2023-09-07 /pmc/articles/PMC10530373/ /pubmed/37761684 http://dx.doi.org/10.3390/healthcare11182487 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anastasescu, Cătălina Mihaela
Gheorman, Veronica
Popescu, Florica
Stoicănescu, Eugen-Cristi
Gheorman, Victor
Riza, Anca-Lelia
Badea, Oana
Streață, Ioana
Militaru, Felicia
Udriștoiu, Ion
Serum Amino Acid Profiling in Children with Autistic Spectrum Disorder: Insights from a Single-Center Study in Southern Romania
title Serum Amino Acid Profiling in Children with Autistic Spectrum Disorder: Insights from a Single-Center Study in Southern Romania
title_full Serum Amino Acid Profiling in Children with Autistic Spectrum Disorder: Insights from a Single-Center Study in Southern Romania
title_fullStr Serum Amino Acid Profiling in Children with Autistic Spectrum Disorder: Insights from a Single-Center Study in Southern Romania
title_full_unstemmed Serum Amino Acid Profiling in Children with Autistic Spectrum Disorder: Insights from a Single-Center Study in Southern Romania
title_short Serum Amino Acid Profiling in Children with Autistic Spectrum Disorder: Insights from a Single-Center Study in Southern Romania
title_sort serum amino acid profiling in children with autistic spectrum disorder: insights from a single-center study in southern romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530373/
https://www.ncbi.nlm.nih.gov/pubmed/37761684
http://dx.doi.org/10.3390/healthcare11182487
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