Cargando…
Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks
BACKGROUND: Brain-based interventions are needed to address persistent relapse in alcohol use disorder (AUD). Neuroimaging evidence suggests higher frontal connectivity as well as higher within-network connectivity of theoretically defined addiction networks are associated with reduced relapse rates...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530485/ https://www.ncbi.nlm.nih.gov/pubmed/37348702 http://dx.doi.org/10.1016/j.brs.2023.06.011 |
_version_ | 1785111518365351936 |
---|---|
author | Camchong, Jazmin Roediger, Donovan Fiecas, Mark Gilmore, Casey S. Kushner, Matt Kummerfeld, Erich Mueller, Bryon A. Lim, Kelvin O. |
author_facet | Camchong, Jazmin Roediger, Donovan Fiecas, Mark Gilmore, Casey S. Kushner, Matt Kummerfeld, Erich Mueller, Bryon A. Lim, Kelvin O. |
author_sort | Camchong, Jazmin |
collection | PubMed |
description | BACKGROUND: Brain-based interventions are needed to address persistent relapse in alcohol use disorder (AUD). Neuroimaging evidence suggests higher frontal connectivity as well as higher within-network connectivity of theoretically defined addiction networks are associated with reduced relapse rates and extended abstinence during follow-up periods. OBJECTIVE: /HYPOTHESIS: A longitudinal randomized double-blind sham-controlled clinical trial investigated whether a non-invasive neuromodulation intervention delivered during early abstinence can (i) modulate connectivity of addiction networks supporting abstinence and (ii) improve relapse rates. Hypotheses: Active transcranial direct current stimulation (tDCS) will (i) increase connectivity of addiction networks known to support abstinence and (ii) reduce relapse rates. METHODS: Short-term abstinent AUD participants (n = 60) were assigned to 5 days of either active tDCS or sham during cognitive training. Causal discovery analysis (CDA) examined the directional influence from left dorsolateral prefrontal cortex (LDLPFC, stimulation site) to addiction networks that support abstinence. RESULTS: Active tDCS had an effect on the average strength of CDA-determined connectivity from LDLPFC to the incentive salience and negative emotionality addiction networks - increasing in the active tDCS group only. Active tDCS had an effect on relapse rates following the intervention, with lower probability of relapse in the active tDCS vs. sham. Active tDCS showed an unexpected sex-dependent effect on relapse rates. CONCLUSION: Our results suggest that LDLPFC stimulation delivered during early abstinence has an effect on addiction networks supporting abstinence and on relapse rates. The unexpected sex-dependent neuromodulation effects need to be further examined in larger clinical trials. |
format | Online Article Text |
id | pubmed-10530485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-105304852023-09-27 Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks Camchong, Jazmin Roediger, Donovan Fiecas, Mark Gilmore, Casey S. Kushner, Matt Kummerfeld, Erich Mueller, Bryon A. Lim, Kelvin O. Brain Stimul Article BACKGROUND: Brain-based interventions are needed to address persistent relapse in alcohol use disorder (AUD). Neuroimaging evidence suggests higher frontal connectivity as well as higher within-network connectivity of theoretically defined addiction networks are associated with reduced relapse rates and extended abstinence during follow-up periods. OBJECTIVE: /HYPOTHESIS: A longitudinal randomized double-blind sham-controlled clinical trial investigated whether a non-invasive neuromodulation intervention delivered during early abstinence can (i) modulate connectivity of addiction networks supporting abstinence and (ii) improve relapse rates. Hypotheses: Active transcranial direct current stimulation (tDCS) will (i) increase connectivity of addiction networks known to support abstinence and (ii) reduce relapse rates. METHODS: Short-term abstinent AUD participants (n = 60) were assigned to 5 days of either active tDCS or sham during cognitive training. Causal discovery analysis (CDA) examined the directional influence from left dorsolateral prefrontal cortex (LDLPFC, stimulation site) to addiction networks that support abstinence. RESULTS: Active tDCS had an effect on the average strength of CDA-determined connectivity from LDLPFC to the incentive salience and negative emotionality addiction networks - increasing in the active tDCS group only. Active tDCS had an effect on relapse rates following the intervention, with lower probability of relapse in the active tDCS vs. sham. Active tDCS showed an unexpected sex-dependent effect on relapse rates. CONCLUSION: Our results suggest that LDLPFC stimulation delivered during early abstinence has an effect on addiction networks supporting abstinence and on relapse rates. The unexpected sex-dependent neuromodulation effects need to be further examined in larger clinical trials. 2023 2023-06-20 /pmc/articles/PMC10530485/ /pubmed/37348702 http://dx.doi.org/10.1016/j.brs.2023.06.011 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Camchong, Jazmin Roediger, Donovan Fiecas, Mark Gilmore, Casey S. Kushner, Matt Kummerfeld, Erich Mueller, Bryon A. Lim, Kelvin O. Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks |
title | Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks |
title_full | Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks |
title_fullStr | Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks |
title_full_unstemmed | Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks |
title_short | Frontal tDCS reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks |
title_sort | frontal tdcs reduces alcohol relapse rates by increasing connections from left dorsolateral prefrontal cortex to addiction networks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530485/ https://www.ncbi.nlm.nih.gov/pubmed/37348702 http://dx.doi.org/10.1016/j.brs.2023.06.011 |
work_keys_str_mv | AT camchongjazmin frontaltdcsreducesalcoholrelapseratesbyincreasingconnectionsfromleftdorsolateralprefrontalcortextoaddictionnetworks AT roedigerdonovan frontaltdcsreducesalcoholrelapseratesbyincreasingconnectionsfromleftdorsolateralprefrontalcortextoaddictionnetworks AT fiecasmark frontaltdcsreducesalcoholrelapseratesbyincreasingconnectionsfromleftdorsolateralprefrontalcortextoaddictionnetworks AT gilmorecaseys frontaltdcsreducesalcoholrelapseratesbyincreasingconnectionsfromleftdorsolateralprefrontalcortextoaddictionnetworks AT kushnermatt frontaltdcsreducesalcoholrelapseratesbyincreasingconnectionsfromleftdorsolateralprefrontalcortextoaddictionnetworks AT kummerfelderich frontaltdcsreducesalcoholrelapseratesbyincreasingconnectionsfromleftdorsolateralprefrontalcortextoaddictionnetworks AT muellerbryona frontaltdcsreducesalcoholrelapseratesbyincreasingconnectionsfromleftdorsolateralprefrontalcortextoaddictionnetworks AT limkelvino frontaltdcsreducesalcoholrelapseratesbyincreasingconnectionsfromleftdorsolateralprefrontalcortextoaddictionnetworks |