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Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice

Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune response by enhancing the activity of regulatory M2 macrophages. The aim of the study was to determine how nematode infection affects age-relate...

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Autores principales: Jermakow, Natalia, Skarżyńska, Weronika, Lewandowska, Katarzyna, Kiernozek, Ewelina, Goździk, Katarzyna, Mietelska-Porowska, Anna, Drela, Nadzieja, Wojda, Urszula, Doligalska, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530578/
https://www.ncbi.nlm.nih.gov/pubmed/37762297
http://dx.doi.org/10.3390/ijms241813994
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author Jermakow, Natalia
Skarżyńska, Weronika
Lewandowska, Katarzyna
Kiernozek, Ewelina
Goździk, Katarzyna
Mietelska-Porowska, Anna
Drela, Nadzieja
Wojda, Urszula
Doligalska, Maria
author_facet Jermakow, Natalia
Skarżyńska, Weronika
Lewandowska, Katarzyna
Kiernozek, Ewelina
Goździk, Katarzyna
Mietelska-Porowska, Anna
Drela, Nadzieja
Wojda, Urszula
Doligalska, Maria
author_sort Jermakow, Natalia
collection PubMed
description Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune response by enhancing the activity of regulatory M2 macrophages. The aim of the study was to determine how nematode infection affects age-related neuroinflammation, especially macrophages in the nervous tissue. Here, intraperitoneal LPS-induced systemic inflammation resulting in brain neurodegeneration was enhanced by prolonged Heligmosomoides polygyrus infection in C57BL/6 mice. The changes in the brain coincided with the increase in M1 macrophages, reduced survivin level, enhanced APP and GFAP expression, chitin-like chains deposition in the brain and deterioration behaviour manifestations. These changes were also observed in transgenic C57BL/6 mice predisposed to develop neurodegeneration typical for Alzheimer’s disease in response to pathogenic stimuli. Interestingly, in mice infected with the nematode only, the greater M2 macrophage population resulted in better results in the forced swim test. Given the growing burden of neurodegenerative diseases, understanding such interactive associations can have significant implications for ageing health strategies and disease monitoring.
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spelling pubmed-105305782023-09-28 Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice Jermakow, Natalia Skarżyńska, Weronika Lewandowska, Katarzyna Kiernozek, Ewelina Goździk, Katarzyna Mietelska-Porowska, Anna Drela, Nadzieja Wojda, Urszula Doligalska, Maria Int J Mol Sci Article Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune response by enhancing the activity of regulatory M2 macrophages. The aim of the study was to determine how nematode infection affects age-related neuroinflammation, especially macrophages in the nervous tissue. Here, intraperitoneal LPS-induced systemic inflammation resulting in brain neurodegeneration was enhanced by prolonged Heligmosomoides polygyrus infection in C57BL/6 mice. The changes in the brain coincided with the increase in M1 macrophages, reduced survivin level, enhanced APP and GFAP expression, chitin-like chains deposition in the brain and deterioration behaviour manifestations. These changes were also observed in transgenic C57BL/6 mice predisposed to develop neurodegeneration typical for Alzheimer’s disease in response to pathogenic stimuli. Interestingly, in mice infected with the nematode only, the greater M2 macrophage population resulted in better results in the forced swim test. Given the growing burden of neurodegenerative diseases, understanding such interactive associations can have significant implications for ageing health strategies and disease monitoring. MDPI 2023-09-12 /pmc/articles/PMC10530578/ /pubmed/37762297 http://dx.doi.org/10.3390/ijms241813994 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jermakow, Natalia
Skarżyńska, Weronika
Lewandowska, Katarzyna
Kiernozek, Ewelina
Goździk, Katarzyna
Mietelska-Porowska, Anna
Drela, Nadzieja
Wojda, Urszula
Doligalska, Maria
Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice
title Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice
title_full Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice
title_fullStr Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice
title_full_unstemmed Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice
title_short Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice
title_sort modulation of lps-induced neurodegeneration by intestinal helminth infection in ageing mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530578/
https://www.ncbi.nlm.nih.gov/pubmed/37762297
http://dx.doi.org/10.3390/ijms241813994
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