Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease

Down syndrome is a genetic anomaly that manifests when there is a mistake during cell division, resulting in an additional chromosome 21. Down syndrome can impact cognitive capabilities and physical development, giving rise to diverse developmental disparities and an elevated likelihood of certain h...

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Autores principales: Yu, Yang, Alonzo, Matthew, Ye, Shiqiao, Fang, Anne, Manickam, Kandamurugu, Garg, Vidu, Zhao, Ming-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530593/
https://www.ncbi.nlm.nih.gov/pubmed/37392705
http://dx.doi.org/10.1016/j.scr.2023.103155
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author Yu, Yang
Alonzo, Matthew
Ye, Shiqiao
Fang, Anne
Manickam, Kandamurugu
Garg, Vidu
Zhao, Ming-Tao
author_facet Yu, Yang
Alonzo, Matthew
Ye, Shiqiao
Fang, Anne
Manickam, Kandamurugu
Garg, Vidu
Zhao, Ming-Tao
author_sort Yu, Yang
collection PubMed
description Down syndrome is a genetic anomaly that manifests when there is a mistake during cell division, resulting in an additional chromosome 21. Down syndrome can impact cognitive capabilities and physical development, giving rise to diverse developmental disparities and an elevated likelihood of certain health issues. The iPSC line NCHi010-A was generated from peripheral blood mononuclear cells of a 6-year-old female with Down syndrome and without congenital heart disease using Sendai virus reprogramming. NCHi010-A displayed a morphology of pluripotent stem cells, expressed pluripotency markers, retained trisomy 21 karyotype, and demonstrated potential to differentiate into cells representative of the three germ layers.
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spelling pubmed-105305932023-09-27 Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease Yu, Yang Alonzo, Matthew Ye, Shiqiao Fang, Anne Manickam, Kandamurugu Garg, Vidu Zhao, Ming-Tao Stem Cell Res Article Down syndrome is a genetic anomaly that manifests when there is a mistake during cell division, resulting in an additional chromosome 21. Down syndrome can impact cognitive capabilities and physical development, giving rise to diverse developmental disparities and an elevated likelihood of certain health issues. The iPSC line NCHi010-A was generated from peripheral blood mononuclear cells of a 6-year-old female with Down syndrome and without congenital heart disease using Sendai virus reprogramming. NCHi010-A displayed a morphology of pluripotent stem cells, expressed pluripotency markers, retained trisomy 21 karyotype, and demonstrated potential to differentiate into cells representative of the three germ layers. 2023-09 2023-06-24 /pmc/articles/PMC10530593/ /pubmed/37392705 http://dx.doi.org/10.1016/j.scr.2023.103155 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Yu, Yang
Alonzo, Matthew
Ye, Shiqiao
Fang, Anne
Manickam, Kandamurugu
Garg, Vidu
Zhao, Ming-Tao
Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease
title Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease
title_full Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease
title_fullStr Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease
title_full_unstemmed Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease
title_short Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease
title_sort generation of an induced pluripotent stem cell line (nchi010-a) from a 6-year-old female with down syndrome and without congenital heart disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530593/
https://www.ncbi.nlm.nih.gov/pubmed/37392705
http://dx.doi.org/10.1016/j.scr.2023.103155
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