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Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints

Drug synergy allows reduced dosing, side effects and tolerance. Optimization of drug synergy chemotherapy is fundamental in acute lymphocytic leukemia and other cancers. This study aimed to analyze the pharmacodynamic synergy between the anti-metabolite cytarabine and WEE1 inhibitor adavosertib on a...

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Detalles Bibliográficos
Autores principales:	Rodríguez-Vázquez, Gabriel O., Diaz-Quiñones, Adriana O., Chorna, Nataliya, Salgado-Villanueva, Iris K., Tang, Jing, Ortiz, Walter I. Silva, Maldonado, Héctor M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530627/ https://www.ncbi.nlm.nih.gov/pubmed/37633054 http://dx.doi.org/10.1016/j.biopha.2023.115352

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