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Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions

Notch signaling is an evolutionarily conserved pathway which functions between adjacent cells to establish their distinct identities. Despite operating in a simple mechanism, Notch signaling plays remarkably diverse roles in development to regulate cell fate determination, organ growth and tissue pa...

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Detalles Bibliográficos
Autores principales: Chen, Yao, Li, Haomiao, Yi, Tian-Ci, Shen, Jie, Zhang, Junzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530718/
https://www.ncbi.nlm.nih.gov/pubmed/37762331
http://dx.doi.org/10.3390/ijms241814028
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author Chen, Yao
Li, Haomiao
Yi, Tian-Ci
Shen, Jie
Zhang, Junzheng
author_facet Chen, Yao
Li, Haomiao
Yi, Tian-Ci
Shen, Jie
Zhang, Junzheng
author_sort Chen, Yao
collection PubMed
description Notch signaling is an evolutionarily conserved pathway which functions between adjacent cells to establish their distinct identities. Despite operating in a simple mechanism, Notch signaling plays remarkably diverse roles in development to regulate cell fate determination, organ growth and tissue patterning. While initially discovered and characterized in the model insect Drosophila melanogaster, recent studies across various insect species have revealed the broad involvement of Notch signaling in shaping insect tissues. This review focuses on providing a comprehensive picture regarding the roles of the Notch pathway in insect development. The roles of Notch in the formation and patterning of the insect embryo, wing, leg, ovary and several specific structures, as well as in physiological responses, are summarized. These results are discussed within the developmental context, aiming to deepen our understanding of the diversified functions of the Notch signaling pathway in different insect species.
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spelling pubmed-105307182023-09-28 Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions Chen, Yao Li, Haomiao Yi, Tian-Ci Shen, Jie Zhang, Junzheng Int J Mol Sci Review Notch signaling is an evolutionarily conserved pathway which functions between adjacent cells to establish their distinct identities. Despite operating in a simple mechanism, Notch signaling plays remarkably diverse roles in development to regulate cell fate determination, organ growth and tissue patterning. While initially discovered and characterized in the model insect Drosophila melanogaster, recent studies across various insect species have revealed the broad involvement of Notch signaling in shaping insect tissues. This review focuses on providing a comprehensive picture regarding the roles of the Notch pathway in insect development. The roles of Notch in the formation and patterning of the insect embryo, wing, leg, ovary and several specific structures, as well as in physiological responses, are summarized. These results are discussed within the developmental context, aiming to deepen our understanding of the diversified functions of the Notch signaling pathway in different insect species. MDPI 2023-09-13 /pmc/articles/PMC10530718/ /pubmed/37762331 http://dx.doi.org/10.3390/ijms241814028 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Yao
Li, Haomiao
Yi, Tian-Ci
Shen, Jie
Zhang, Junzheng
Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions
title Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions
title_full Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions
title_fullStr Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions
title_full_unstemmed Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions
title_short Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions
title_sort notch signaling in insect development: a simple pathway with diverse functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530718/
https://www.ncbi.nlm.nih.gov/pubmed/37762331
http://dx.doi.org/10.3390/ijms241814028
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AT shenjie notchsignalingininsectdevelopmentasimplepathwaywithdiversefunctions
AT zhangjunzheng notchsignalingininsectdevelopmentasimplepathwaywithdiversefunctions