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Fucoxanthin Ameliorates Sepsis via Modulating Microbiota by Targeting IRF3 Activation

To improve patient survival in sepsis, it is necessary to curtail exaggerated inflammatory responses. Fucoxanthin (FX), a carotenoid derived from brown algae, efficiently suppresses pro-inflammatory cytokine expression via IRF3 activation, thereby reducing mortality in a mouse model of sepsis. Howev...

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Autores principales: Su, Jingqian, Guan, Biyun, Su, Qiaofen, Hu, Shan, Wu, Shun, Tong, Zhiyong, Zhou, Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530764/
https://www.ncbi.nlm.nih.gov/pubmed/37762104
http://dx.doi.org/10.3390/ijms241813803
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author Su, Jingqian
Guan, Biyun
Su, Qiaofen
Hu, Shan
Wu, Shun
Tong, Zhiyong
Zhou, Fen
author_facet Su, Jingqian
Guan, Biyun
Su, Qiaofen
Hu, Shan
Wu, Shun
Tong, Zhiyong
Zhou, Fen
author_sort Su, Jingqian
collection PubMed
description To improve patient survival in sepsis, it is necessary to curtail exaggerated inflammatory responses. Fucoxanthin (FX), a carotenoid derived from brown algae, efficiently suppresses pro-inflammatory cytokine expression via IRF3 activation, thereby reducing mortality in a mouse model of sepsis. However, the effects of FX-targeted IRF3 on the bacterial flora (which is disrupted in sepsis) and the mechanisms by which it impacts sepsis development remain unclear. This study aims to elucidate how FX-targeted IRF3 modulates intestinal microbiota compositions, influencing sepsis development. FX significantly reduced the bacterial load in the abdominal cavity of mice with cecal ligation and puncture (CLP)-induced sepsis via IRF3 activation and increased short-chain fatty acids, like acetic and propionic acids, with respect to their intestines. FX also altered the structure of the intestinal flora, notably elevating beneficial Verrucomicrobiota and Akkermansia spp. while reducing harmful Morganella spp. Investigating the inflammation–flora link, we found positive correlations between the abundances of Morganella spp., Proteus spp., Escherichia spp., and Klebsiella spp. and pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) induced by CLP. These bacteria were negatively correlated with acetic and propionic acid production. FX alters microbial diversity and promotes short-chain fatty acid production in mice with CLP-induced sepsis, reshaping gut homeostasis. These findings support the value of FX for the treatment of sepsis.
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spelling pubmed-105307642023-09-28 Fucoxanthin Ameliorates Sepsis via Modulating Microbiota by Targeting IRF3 Activation Su, Jingqian Guan, Biyun Su, Qiaofen Hu, Shan Wu, Shun Tong, Zhiyong Zhou, Fen Int J Mol Sci Article To improve patient survival in sepsis, it is necessary to curtail exaggerated inflammatory responses. Fucoxanthin (FX), a carotenoid derived from brown algae, efficiently suppresses pro-inflammatory cytokine expression via IRF3 activation, thereby reducing mortality in a mouse model of sepsis. However, the effects of FX-targeted IRF3 on the bacterial flora (which is disrupted in sepsis) and the mechanisms by which it impacts sepsis development remain unclear. This study aims to elucidate how FX-targeted IRF3 modulates intestinal microbiota compositions, influencing sepsis development. FX significantly reduced the bacterial load in the abdominal cavity of mice with cecal ligation and puncture (CLP)-induced sepsis via IRF3 activation and increased short-chain fatty acids, like acetic and propionic acids, with respect to their intestines. FX also altered the structure of the intestinal flora, notably elevating beneficial Verrucomicrobiota and Akkermansia spp. while reducing harmful Morganella spp. Investigating the inflammation–flora link, we found positive correlations between the abundances of Morganella spp., Proteus spp., Escherichia spp., and Klebsiella spp. and pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) induced by CLP. These bacteria were negatively correlated with acetic and propionic acid production. FX alters microbial diversity and promotes short-chain fatty acid production in mice with CLP-induced sepsis, reshaping gut homeostasis. These findings support the value of FX for the treatment of sepsis. MDPI 2023-09-07 /pmc/articles/PMC10530764/ /pubmed/37762104 http://dx.doi.org/10.3390/ijms241813803 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Jingqian
Guan, Biyun
Su, Qiaofen
Hu, Shan
Wu, Shun
Tong, Zhiyong
Zhou, Fen
Fucoxanthin Ameliorates Sepsis via Modulating Microbiota by Targeting IRF3 Activation
title Fucoxanthin Ameliorates Sepsis via Modulating Microbiota by Targeting IRF3 Activation
title_full Fucoxanthin Ameliorates Sepsis via Modulating Microbiota by Targeting IRF3 Activation
title_fullStr Fucoxanthin Ameliorates Sepsis via Modulating Microbiota by Targeting IRF3 Activation
title_full_unstemmed Fucoxanthin Ameliorates Sepsis via Modulating Microbiota by Targeting IRF3 Activation
title_short Fucoxanthin Ameliorates Sepsis via Modulating Microbiota by Targeting IRF3 Activation
title_sort fucoxanthin ameliorates sepsis via modulating microbiota by targeting irf3 activation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530764/
https://www.ncbi.nlm.nih.gov/pubmed/37762104
http://dx.doi.org/10.3390/ijms241813803
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