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Infection Prevention Control Strategies of New Delhi Metallo-β-lactamase Producing Klebsiella pneumoniae

The spread of multi-drug resistant organisms (MDROs) is increasing at an alarming rate worldwide. Among these, Carbapenemase-producing New Delhi Metallo-β-lactamase (NDM) poses a significant clinical threat, and appropriate measures must be taken to prevent or limit its penetration into still-free t...

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Autores principales: Muresu, Narcisa, Deiana, Giovanna, Dettori, Marco, Palmieri, Alessandra, Masia, Maria Dolores, Cossu, Andrea, D’Avino, Cristina, Sechi, Illari, Del Rio, Arcadia, Piana, Andrea, Castiglia, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530878/
https://www.ncbi.nlm.nih.gov/pubmed/37761789
http://dx.doi.org/10.3390/healthcare11182592
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author Muresu, Narcisa
Deiana, Giovanna
Dettori, Marco
Palmieri, Alessandra
Masia, Maria Dolores
Cossu, Andrea
D’Avino, Cristina
Sechi, Illari
Del Rio, Arcadia
Piana, Andrea
Castiglia, Paolo
author_facet Muresu, Narcisa
Deiana, Giovanna
Dettori, Marco
Palmieri, Alessandra
Masia, Maria Dolores
Cossu, Andrea
D’Avino, Cristina
Sechi, Illari
Del Rio, Arcadia
Piana, Andrea
Castiglia, Paolo
author_sort Muresu, Narcisa
collection PubMed
description The spread of multi-drug resistant organisms (MDROs) is increasing at an alarming rate worldwide. Among these, Carbapenemase-producing New Delhi Metallo-β-lactamase (NDM) poses a significant clinical threat, and appropriate measures must be taken to prevent or limit its penetration into still-free territories. The present report describes two independent cases of patients from Ukraine colonized by NDM-producing Klebsiella pneumoniae and admitted to two separate wards of an acute university hospital in a territory not yet affected by Carbapenemase producers of this class. Moreover, this report illustrates the infection prevention control (IPC) strategies promptly implemented by the IPC operational team to verify the possible spread of the microorganism in the ward and avoid any possible further contamination. The identification of genes coding for Carbapenemases, performed using real-time PCR, revealed no other cases within the wards involved. These cases emphasize the importance of early case recognition of multidrug-resistant bacteria, the necessity of effective inter-hospital communication, the need for effective antimicrobial stewardship protocol, and the importance of adequate IPC policies. Additionally, we highlight the need to improve screening procedures in the case of patients from countries with a high prevalence of MDRO, as essential measures to prevent potential nosocomial outbreaks and/or endemization.
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spelling pubmed-105308782023-09-28 Infection Prevention Control Strategies of New Delhi Metallo-β-lactamase Producing Klebsiella pneumoniae Muresu, Narcisa Deiana, Giovanna Dettori, Marco Palmieri, Alessandra Masia, Maria Dolores Cossu, Andrea D’Avino, Cristina Sechi, Illari Del Rio, Arcadia Piana, Andrea Castiglia, Paolo Healthcare (Basel) Case Report The spread of multi-drug resistant organisms (MDROs) is increasing at an alarming rate worldwide. Among these, Carbapenemase-producing New Delhi Metallo-β-lactamase (NDM) poses a significant clinical threat, and appropriate measures must be taken to prevent or limit its penetration into still-free territories. The present report describes two independent cases of patients from Ukraine colonized by NDM-producing Klebsiella pneumoniae and admitted to two separate wards of an acute university hospital in a territory not yet affected by Carbapenemase producers of this class. Moreover, this report illustrates the infection prevention control (IPC) strategies promptly implemented by the IPC operational team to verify the possible spread of the microorganism in the ward and avoid any possible further contamination. The identification of genes coding for Carbapenemases, performed using real-time PCR, revealed no other cases within the wards involved. These cases emphasize the importance of early case recognition of multidrug-resistant bacteria, the necessity of effective inter-hospital communication, the need for effective antimicrobial stewardship protocol, and the importance of adequate IPC policies. Additionally, we highlight the need to improve screening procedures in the case of patients from countries with a high prevalence of MDRO, as essential measures to prevent potential nosocomial outbreaks and/or endemization. MDPI 2023-09-20 /pmc/articles/PMC10530878/ /pubmed/37761789 http://dx.doi.org/10.3390/healthcare11182592 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Muresu, Narcisa
Deiana, Giovanna
Dettori, Marco
Palmieri, Alessandra
Masia, Maria Dolores
Cossu, Andrea
D’Avino, Cristina
Sechi, Illari
Del Rio, Arcadia
Piana, Andrea
Castiglia, Paolo
Infection Prevention Control Strategies of New Delhi Metallo-β-lactamase Producing Klebsiella pneumoniae
title Infection Prevention Control Strategies of New Delhi Metallo-β-lactamase Producing Klebsiella pneumoniae
title_full Infection Prevention Control Strategies of New Delhi Metallo-β-lactamase Producing Klebsiella pneumoniae
title_fullStr Infection Prevention Control Strategies of New Delhi Metallo-β-lactamase Producing Klebsiella pneumoniae
title_full_unstemmed Infection Prevention Control Strategies of New Delhi Metallo-β-lactamase Producing Klebsiella pneumoniae
title_short Infection Prevention Control Strategies of New Delhi Metallo-β-lactamase Producing Klebsiella pneumoniae
title_sort infection prevention control strategies of new delhi metallo-β-lactamase producing klebsiella pneumoniae
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530878/
https://www.ncbi.nlm.nih.gov/pubmed/37761789
http://dx.doi.org/10.3390/healthcare11182592
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