Role of Rho/MRTF in Aggressive Vemurafenib-Resistant Murine Melanomas and Immune Checkpoint Upregulation

Cutaneous melanoma is the deadliest skin cancer. Most have Ras-MAPK pathway (BRAF(V600E) or NRAS) mutations and highly effective targeted therapies exist; however, they and immune therapies are limited by resistance, in part driven by small GTPase (Rho and Rac) activation. To facilitate preclinical...

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Detalles Bibliográficos
Autores principales: Foda, Bardees M., Neubig, Richard R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531039/
https://www.ncbi.nlm.nih.gov/pubmed/37762086
http://dx.doi.org/10.3390/ijms241813785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531039/
https://www.ncbi.nlm.nih.gov/pubmed/37762086
http://dx.doi.org/10.3390/ijms241813785

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