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Role of Rho/MRTF in Aggressive Vemurafenib-Resistant Murine Melanomas and Immune Checkpoint Upregulation
Cutaneous melanoma is the deadliest skin cancer. Most have Ras-MAPK pathway (BRAF(V600E) or NRAS) mutations and highly effective targeted therapies exist; however, they and immune therapies are limited by resistance, in part driven by small GTPase (Rho and Rac) activation. To facilitate preclinical...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531039/ https://www.ncbi.nlm.nih.gov/pubmed/37762086 http://dx.doi.org/10.3390/ijms241813785 |