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PDT-Induced Activation Enhanced by Hormone Response to Treatment

Photodynamic therapy (PDT) is a medical treatment with the use of a photosensitizing agent (PS), which, when activated by light, results in selective tissue damage with a cytotoxic effect on tumor cells. PDT leads to the induction of an acute-phase response, which results in the involvement of adren...

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Autores principales: Domka, Wojciech, Bartusik-Aebisher, Dorota, Przygoda, Maria, Dynarowicz, Klaudia, Tomik, Jerzy, Aebisher, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531063/
https://www.ncbi.nlm.nih.gov/pubmed/37762219
http://dx.doi.org/10.3390/ijms241813917
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author Domka, Wojciech
Bartusik-Aebisher, Dorota
Przygoda, Maria
Dynarowicz, Klaudia
Tomik, Jerzy
Aebisher, David
author_facet Domka, Wojciech
Bartusik-Aebisher, Dorota
Przygoda, Maria
Dynarowicz, Klaudia
Tomik, Jerzy
Aebisher, David
author_sort Domka, Wojciech
collection PubMed
description Photodynamic therapy (PDT) is a medical treatment with the use of a photosensitizing agent (PS), which, when activated by light, results in selective tissue damage with a cytotoxic effect on tumor cells. PDT leads to the induction of an acute-phase response, which results in the involvement of adrenal glucocorticoid (GC) hormones. PDT, by activating the hormonal response, affects the treatment of cancer. GC release is observed due to adrenal activity, which is driven by changes in the hypothalamic pituitary–adrenal axis triggered by stress signals emanating from the PDT treated tumor. The hormones released in this process in the context of the PDT-induced acute-phase response perform many important functions during anticancer therapy. They lead, among other things, to the systemic mobilization of neutrophils and the production of acute-phase reagents, and also control the production of immunoregulatory proteins and proteins that modulate inflammation. GCs can radically affect the activity of various inflammatory and immune cells, including the apoptosis of cancer cells. A better understanding of the modulation of GC activity could improve the outcomes of cancer patients treated with PDT.
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spelling pubmed-105310632023-09-28 PDT-Induced Activation Enhanced by Hormone Response to Treatment Domka, Wojciech Bartusik-Aebisher, Dorota Przygoda, Maria Dynarowicz, Klaudia Tomik, Jerzy Aebisher, David Int J Mol Sci Review Photodynamic therapy (PDT) is a medical treatment with the use of a photosensitizing agent (PS), which, when activated by light, results in selective tissue damage with a cytotoxic effect on tumor cells. PDT leads to the induction of an acute-phase response, which results in the involvement of adrenal glucocorticoid (GC) hormones. PDT, by activating the hormonal response, affects the treatment of cancer. GC release is observed due to adrenal activity, which is driven by changes in the hypothalamic pituitary–adrenal axis triggered by stress signals emanating from the PDT treated tumor. The hormones released in this process in the context of the PDT-induced acute-phase response perform many important functions during anticancer therapy. They lead, among other things, to the systemic mobilization of neutrophils and the production of acute-phase reagents, and also control the production of immunoregulatory proteins and proteins that modulate inflammation. GCs can radically affect the activity of various inflammatory and immune cells, including the apoptosis of cancer cells. A better understanding of the modulation of GC activity could improve the outcomes of cancer patients treated with PDT. MDPI 2023-09-10 /pmc/articles/PMC10531063/ /pubmed/37762219 http://dx.doi.org/10.3390/ijms241813917 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Domka, Wojciech
Bartusik-Aebisher, Dorota
Przygoda, Maria
Dynarowicz, Klaudia
Tomik, Jerzy
Aebisher, David
PDT-Induced Activation Enhanced by Hormone Response to Treatment
title PDT-Induced Activation Enhanced by Hormone Response to Treatment
title_full PDT-Induced Activation Enhanced by Hormone Response to Treatment
title_fullStr PDT-Induced Activation Enhanced by Hormone Response to Treatment
title_full_unstemmed PDT-Induced Activation Enhanced by Hormone Response to Treatment
title_short PDT-Induced Activation Enhanced by Hormone Response to Treatment
title_sort pdt-induced activation enhanced by hormone response to treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531063/
https://www.ncbi.nlm.nih.gov/pubmed/37762219
http://dx.doi.org/10.3390/ijms241813917
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