Furmonertinib, a Third-Generation EGFR Tyrosine Kinase Inhibitor, Overcomes Multidrug Resistance through Inhibiting ABCB1 and ABCG2 in Cancer Cells

ATP-binding cassette transporters, including ABCB1 (P-glycoprotein) and ABCG2 (BCRP/MXR/ABCP), are pivotal in multidrug resistance (MDR) development in cancer patients undergoing conventional chemotherapy. The absence of approved therapeutic agents for multidrug-resistant cancers presents a signific...

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Detalles Bibliográficos
Autores principales: Wu, Chung-Pu, Li, Yen-Ching, Murakami, Megumi, Hsiao, Sung-Han, Lee, Yun-Chieh, Huang, Yang-Hui, Chang, Yu-Tzu, Hung, Tai-Ho, Wu, Yu-Shan, Ambudkar, Suresh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531071/
https://www.ncbi.nlm.nih.gov/pubmed/37762275
http://dx.doi.org/10.3390/ijms241813972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531071/
https://www.ncbi.nlm.nih.gov/pubmed/37762275
http://dx.doi.org/10.3390/ijms241813972

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