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Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam
Osteoarthritis (OA) is the degeneration of cartilage in joints that results in bones rubbing against each other; it causes uncomfortable symptoms such as pain, swelling, and stiffness and can lead to disability. It usually occurs in the elderly and causes a large medical burden. The aim of this stud...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531128/ https://www.ncbi.nlm.nih.gov/pubmed/37761699 http://dx.doi.org/10.3390/healthcare11182502 |
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author | Vo, Nam Xuan Che, Uyen Thi Thuc Ngo, Thanh Thi Thanh Bui, Tien Thuy |
author_facet | Vo, Nam Xuan Che, Uyen Thi Thuc Ngo, Thanh Thi Thanh Bui, Tien Thuy |
author_sort | Vo, Nam Xuan |
collection | PubMed |
description | Osteoarthritis (OA) is the degeneration of cartilage in joints that results in bones rubbing against each other; it causes uncomfortable symptoms such as pain, swelling, and stiffness and can lead to disability. It usually occurs in the elderly and causes a large medical burden. The aim of this study is to evaluate the cost-effectiveness between the standard treatment for osteoarthritis and standard treatment with added crystalline glucosamine sulfate at various stages. Markov analysis modeling was applied to evaluate the effect of both adding glucosamine compared to standard treatment from a societal perspective during whole patients’ lifetimes. Data input was collected from reviews in previous studies. The outcome was measured in quality-adjusted life years (QALYs), and the Incremental Cost-Effectiveness Ratio (ICER) from a societal perspective was applied with 3% and discounted for all costs and outcomes. One-way analysis via the Tornado diagram was performed to investigate the change in factors in the model. In general, adding glucosamine into the standard treatment proved to be more cost-effective compared to the standard treatment. Particularly, the early-stage addition of glucosamine in the treatment was cost-effective compared to the post-stage addition of glucosamine. The addition of supplementing crystalline glucosamine sulfate to the whole regimen at any stage was cost-effective at the willingness-to-pay (WTP) threshold. |
format | Online Article Text |
id | pubmed-10531128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105311282023-09-28 Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam Vo, Nam Xuan Che, Uyen Thi Thuc Ngo, Thanh Thi Thanh Bui, Tien Thuy Healthcare (Basel) Article Osteoarthritis (OA) is the degeneration of cartilage in joints that results in bones rubbing against each other; it causes uncomfortable symptoms such as pain, swelling, and stiffness and can lead to disability. It usually occurs in the elderly and causes a large medical burden. The aim of this study is to evaluate the cost-effectiveness between the standard treatment for osteoarthritis and standard treatment with added crystalline glucosamine sulfate at various stages. Markov analysis modeling was applied to evaluate the effect of both adding glucosamine compared to standard treatment from a societal perspective during whole patients’ lifetimes. Data input was collected from reviews in previous studies. The outcome was measured in quality-adjusted life years (QALYs), and the Incremental Cost-Effectiveness Ratio (ICER) from a societal perspective was applied with 3% and discounted for all costs and outcomes. One-way analysis via the Tornado diagram was performed to investigate the change in factors in the model. In general, adding glucosamine into the standard treatment proved to be more cost-effective compared to the standard treatment. Particularly, the early-stage addition of glucosamine in the treatment was cost-effective compared to the post-stage addition of glucosamine. The addition of supplementing crystalline glucosamine sulfate to the whole regimen at any stage was cost-effective at the willingness-to-pay (WTP) threshold. MDPI 2023-09-08 /pmc/articles/PMC10531128/ /pubmed/37761699 http://dx.doi.org/10.3390/healthcare11182502 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vo, Nam Xuan Che, Uyen Thi Thuc Ngo, Thanh Thi Thanh Bui, Tien Thuy Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam |
title | Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam |
title_full | Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam |
title_fullStr | Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam |
title_full_unstemmed | Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam |
title_short | Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam |
title_sort | economic evaluation of glucosamine in knee osteoarthritis treatments in vietnam |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10531128/ https://www.ncbi.nlm.nih.gov/pubmed/37761699 http://dx.doi.org/10.3390/healthcare11182502 |
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